2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. CCW 28-3

CCW 28-3 is a PROTAC-based BRD4 degrader in a proteasome- and RNF4-dependent manner (Pink: JQ-1 (carboxylic acid) (HY-78695); Black: linker (HY-170384); Blue: RNF4 ligand CCW16 (HY-143346)).

For research use only. We do not sell to patients.

CCW 28-3

CCW 28-3 Chemical Structure

CAS No. : 2361142-23-4

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CCW 28-3 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

CCW 28-3 is a PROTAC-based BRD4 degrader in a proteasome- and RNF4-dependent manner (Pink: JQ-1 (carboxylic acid) (HY-78695); Black: linker (HY-170384); Blue: RNF4 ligand CCW16 (HY-143346))[1].

Molecular Weight

821.81

Formula

C44H42Cl2N6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCl)N(C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)CC7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (121.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2168 mL 6.0841 mL 12.1683 mL
5 mM 0.2434 mL 1.2168 mL 2.4337 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2168 mL 6.0841 mL 12.1683 mL 30.4207 mL
5 mM 0.2434 mL 1.2168 mL 2.4337 mL 6.0841 mL
10 mM 0.1217 mL 0.6084 mL 1.2168 mL 3.0421 mL
15 mM 0.0811 mL 0.4056 mL 0.8112 mL 2.0280 mL
20 mM 0.0608 mL 0.3042 mL 0.6084 mL 1.5210 mL
25 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2168 mL
30 mM 0.0406 mL 0.2028 mL 0.4056 mL 1.0140 mL
40 mM 0.0304 mL 0.1521 mL 0.3042 mL 0.7605 mL
50 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6084 mL
60 mM 0.0203 mL 0.1014 mL 0.2028 mL 0.5070 mL
80 mM 0.0152 mL 0.0761 mL 0.1521 mL 0.3803 mL
100 mM 0.0122 mL 0.0608 mL 0.1217 mL 0.3042 mL
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CCW 28-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCW 28-32361142-23-4PROTACsEpigenetic Reader DomainInhibitorinhibitorinhibit

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