2361142-23-4
2361142-23-4
Chemical Structure
CCW 28-3
- CAS No.: 2361142-23-4
- Formula:C44H42Cl2N6O4S
- Molecular Weight:821.81
InChIKey: WSSWVTZWODGGCO-LHEWISCISA-N
SMILES: O=C(CCl)N(C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)CC7=CC=CC=C7
Biological Activity: CCW 28-3 is a BRD4 PROTAC degrader. CCW 28-3 recruits RNF4 to BRD4, inducing RNF4-dependent ubiquitination and proteasomal degradation of BRD4. CCW 28-3 can be used in breast cancer-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CCW 28-3 | 99.38% | CCW 28-3 is a BRD4 PROTAC degrader. CCW 28-3 recruits RNF4 to BRD4, inducing RNF4-dependent ubiquitination and proteasomal degradation of BRD4. CCW 28-3 can be used in breast cancer-related research. | ||||||||||||||||||||
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References
- [1]. Ward CC, et al. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS chemical biology. 2019 Nov 15;14(11):2430-2440. [Content Brief]
- [2]. Kiely-Collins H, et al. The role of reversible and irreversible covalent chemistry in targeted protein degradation. Cell Chem Biol. 2021 Jul 15;28(7):952-968. [Content Brief]
