KBTBD8 - kelch repeat and BTB domain containing 8 Gene
Also Known as TAKRP; TA-KRP
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 84541
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in neural crest cell development; neural crest formation; and protein monoubiquitination. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in lymph node (RPKM 10.1), testis (RPKM 4.7) and 14 other tissues.
KBTBD8 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_032505.3 | NP_115894.2 | kelch repeat and BTB domain-containing protein 8 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21145461 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in neural crest cell development |
IMP
IMP: Inferred from mutant phenotype
|
26399832 | GOA |
| involved in neural crest formation |
IMP
IMP: Inferred from mutant phenotype
|
26399832 | GOA |
| involved in protein monoubiquitination |
IDA
IDA: Inferred from direct assay
|
26399832 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| part of Cul3-RING ubiquitin ligase complex |
IDA
IDA: Inferred from direct assay
|
26399832 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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KBTBD8 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
KBTBD8 | Q8NFY9 | CUL3 | Homo sapiens | Q13618 | 30190310 | |
|
Intra
|
KBTBD8 | Q8NFY9 | KBTBD7 | Homo sapiens | Q8WVZ9 | 30190310 | |
|
Intra
|
KBTBD8 | Q8NFY9 | KBTBD7 | Homo sapiens | Q8WVZ9 | 30190310 | |
|
Intra
|
KBTBD8 | Q8NFY9 | FBXL17 | Homo sapiens | Q9UF56 | 30190310 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
KBTBD8 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P84678 | KBTBD8 Antibody (YA4375) | WB, FC, ELISA | Human |
| HY-P84678A | KBTBD8 Antibody (YA4375)(PBS only) | WB, FC, ELISA | Human |