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KBTBD8 Antibody (YA4375)(PBS only)

(Synonyms: TA-KRP)

KBTBD8 Antibody (YA4375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KBTBD8.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • KBTBD8 Antibody (YA4375)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:2000 1:200-1:400 1:10000

Product Details

Description

KBTBD8 Antibody (YA4375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KBTBD8.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 69 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 69 kDa
Immunogen

Purified recombinant fragment of human KBTBD8 (AA: 264-464) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    KBTBD8 is a Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification[1].

  • Subcellular Localization

    Cytoplasm, cytoskeleton, spindle; Golgi apparatus

  • Isoforms & Post-Translational Modification

    Q8NFY9 has 2 isomers: Q8NFY9-1: 68823 Da (predicted); Q8NFY9-2: 18827 Da (predicted).

  • Subunit

    Component of the BCR(KBTBD8) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD8 and RBX1 (PubMed:26399832)

  • SwissProt ID

    Q8NFY9

  • Gene ID
    84541 [NCBI]
  • Synonyms

    TA-KRP

KBTBD8 Antibody (YA4375)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • KBTBD8 Antibody (YA4375)(PBS only) Product Image
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  • KBTBD8 Antibody (YA4375)(PBS only) Product Image