FBXL17 - F-box and leucine rich repeat protein 17 Gene

Also Known as Fbl17; Fbx13; FBXO13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64839

About FBXL17

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:107,859,035-108,382,098 (from NCBI)

This gene has 4 transcripts (splice variants), 236 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 4.5), brain (RPKM 4.2) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL17 Products (1)

mRNA	Protein	Name
NM_001163315.3	NP_001156787.2	F-box/LRR-repeat protein 17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24035498	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24035498	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	30190310	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	27234298	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IDA IDA: Inferred from direct assay	30190310	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	24035498	GOA
involved in regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	27234298	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	24035498	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24035498	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24035498	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL17 Protein Structure

F-box-like

0
200
400
600
701 a.a.

Protein Preferred Names	Protein Names
F-box/LRR-repeat protein 17	F-box only protein 13

FBXL17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXL17	Q9UF56	SPAST	Homo sapiens	Q9UBP0	Protein Array	35869491
Intra	FBXL17	Q9UF56	KBTBD8	Homo sapiens	Q8NFY9	Anti Tag CoIP	30190310
Intra	FBXL17	Q9UF56	SKP1	Homo sapiens	P63208	Anti Tag CoIP	30190310
Intra	FBXL17	Q9UF56	SKP1	Homo sapiens	P63208	Pull Down	30190310
Intra	FBXL17	Q9UF56	SPAST	Homo sapiens	Q9UBP0-1	Pull Down	35869491
Intra	FBXL17	Q9UF56	SPAST	Homo sapiens	Q9UBP0-1	Anti Tag CoIP	35869491
Intra	FBXL17	Q9UF56	KLHL12	Homo sapiens	Q53G59	Anti Tag CoIP	30190310
Intra	FBXL17	Q9UF56	KLHL12	Homo sapiens	Q53G59	Pull Down	30190310

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Cardiac Arrhythmia	Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome IDDCA Intellectual Developmental Disorder, With Cardiac Arrhythmia
Proprotein Convertase 1/3 Deficiency	Obesity Due To Prohormone Convertase I Deficiency Obesity With Impaired Prohormone Processing Obesity And Endocrinopathy Due To Impaired Processing Of Prohormones Pci Deficiency Proprotein Convertase 1 3 Deficiency Endocrinopathy Due To Proprotein Convertase 1/3 Deficiency Proprotein Convertase 1 Deficiency PC1 DEFICIENCY
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04786	FBXL17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBXL17	MGD	MGI:1354704
Canis familiaris	FBXL17	VGNC	VGNC:59022
Macaca mulatta	FBXL17	VGNC	VGNC:82142
Felis catus	FBXL17	VGNC	VGNC:102205
Bos taurus	FBXL17	VGNC	VGNC:106738
Rattus norvegicus	FBXL17	RGD	RGD:1309773
Others	FBXL17	NCBI