KLHL8 - kelch like family member 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57563

Summary

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in thyroid (RPKM 11.3), kidney (RPKM 6.2) and 25 other tissues.

KLHL8 Products (4)

mRNA Protein Name
NM_001292003.2 NP_001278932.1 kelch-like protein 8 isoform 1
NM_001292006.2 NP_001278935.1 kelch-like protein 8 isoform 2
NM_001292007.2 NP_001278936.1 kelch-like protein 8 isoform 3
NM_020803.5 NP_065854.3 kelch-like protein 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
Biological Process GO Annotation Evidence References Source
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19158078 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19158078 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
19158078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHL8 Q9P2G9 CUL3 Homo sapiens Q13618
Anti Tag CoIP
30190310
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-136250A BSJ-03-204 triTFA Inhibitor 99.87% Unkown