Nrf2 activator-10

Cat. No.: HY-124834 Purity: 98.65%: Data Sheet
COA

SDS
Handling Instructions
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Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC₅₀ is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H₂O₂-induced apoptosis.

For research use only. We do not sell to patients.

Nrf2 activator-10 Chemical Structure

CAS No. : 75483-04-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

265.69

Formula

C₁₃H₁₂ClNO₃

CAS No.

75483-04-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(Cl)C2=C(C=CC=C2)N(C)C1=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (188.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7638 mL	18.8189 mL	37.6378 mL
5 mM	0.7528 mL	3.7638 mL	7.5276 mL
10 mM	0.3764 mL	1.8819 mL	3.7638 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.65%

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Data Sheet (270 KB) SDS (393 KB)

COA (249 KB) HNMR (241 KB) RP-HPLC (251 KB) MS (229 KB)

Handling Instructions (2659 KB)

References

[1]. Hur W, et al., A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28;17(5):537-47. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7638 mL	18.8189 mL	37.6378 mL	94.0946 mL
	5 mM	0.7528 mL	3.7638 mL	7.5276 mL	18.8189 mL
	10 mM	0.3764 mL	1.8819 mL	3.7638 mL	9.4095 mL
	15 mM	0.2509 mL	1.2546 mL	2.5092 mL	6.2730 mL
	20 mM	0.1882 mL	0.9409 mL	1.8819 mL	4.7047 mL
	25 mM	0.1506 mL	0.7528 mL	1.5055 mL	3.7638 mL
	30 mM	0.1255 mL	0.6273 mL	1.2546 mL	3.1365 mL
	40 mM	0.0941 mL	0.4705 mL	0.9409 mL	2.3524 mL
	50 mM	0.0753 mL	0.3764 mL	0.7528 mL	1.8819 mL
	60 mM	0.0627 mL	0.3136 mL	0.6273 mL	1.5682 mL
	80 mM	0.0470 mL	0.2352 mL	0.4705 mL	1.1762 mL
	100 mM	0.0376 mL	0.1882 mL	0.3764 mL	0.9409 mL