75483-04-4

Nrf2 activator-10 Chemical Structure
75483-04-4

Chemical Structure

Nrf2 activator-10

  • CAS No.: 75483-04-4
  • Formula:C13H12ClNO3
  • Molecular Weight:265.69

IUPAC Name: ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

InChIKey: XUJQDJGGHFNYDY-UHFFFAOYSA-N

SMILES: O=C(C1=C(Cl)C2=C(C=CC=C2)N(C)C1=O)OCC

Biological Activity: Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.

Cat. No. Product Name Purity Description Pricing
HY-124834 		Nrf2 activator-10 98.65% Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
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