KLHL20 - kelch like family member 20 Gene

Also Known as KHLHX; KLEIP; KLHLX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27252

About KLHL20

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,714,981-173,786,692 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 54 paralogues. Ubiquitous expression in testis (RPKM 10.0), fat (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]

KLHL20 Products (1)

mRNA Protein Name
NM_014458.4 NP_055273.2 kelch-like protein 20

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20389280 GOA
enables type II interferon binding IDA
IDA: Inferred from direct assay
20389280 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
24768539 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20389280 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi to endosome transport IMP
IMP: Inferred from mutant phenotype
24768539 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20389280 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20389280 GOA
involved in protein K33-linked ubiquitination IDA
IDA: Inferred from direct assay
24768539 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
20389280 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
20389280 GOA
located in PML body IDA
IDA: Inferred from direct assay
20389280 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20389280 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
24768539 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL20 Protein Structure

BTB

BTB: BTB/POZ domain (59 - 164)

BACK

BACK: BTB And C-terminal Kelch (170 - 270)

Kelch_1

Kelch_1: Kelch motif (317 - 352)

Kelch_1

Kelch_1: Kelch motif (354 - 393)

Kelch_1

Kelch_1: Kelch motif (403 - 447)

Kelch_1

Kelch_1: Kelch motif (449 - 493)

Kelch_1

Kelch_1: Kelch motif (496 - 538)

Kelch_1

Kelch_1: Kelch motif (543 - 583)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 609 a.a.
Protein Preferred Names Protein Names

kelch-like protein 20

  • Kelch motif containing protein

KLHL20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHL20 Q9Y2M5 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 GIPC1 Homo sapiens O14908-2
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 GIPC1 Homo sapiens O14908-2
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 GIPC1 Homo sapiens O14908-2
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 PML Homo sapiens P29590
Pull Down
21840486
Intra
KLHL20 Q9Y2M5 PML Homo sapiens P29590
IF
20389280
Intra
KLHL20 Q9Y2M5 PML Homo sapiens P29590
Anti Tag CoIP
20389280
Intra
KLHL20 Q9Y2M5 PML Homo sapiens P29590
Anti Tag CoIP
25619834
Intra
KLHL20 Q9Y2M5 PML Homo sapiens P29590-1
Anti Tag CoIP
21840486
Intra
KLHL20 Q9Y2M5 PML Homo sapiens P29590-1
Pull Down
25619834
Intra
KLHL20 Q9Y2M5 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 DAPK1 Homo sapiens P53355
Anti Bait CoIP
20389280
Intra
KLHL20 Q9Y2M5 DAPK1 Homo sapiens P53355
Anti Tag CoIP
20389280
Intra
KLHL20 Q9Y2M5 DAPK1 Homo sapiens P53355
Anti Tag CoIP
25619834
Intra
KLHL20 Q9Y2M5 DAPK1 Homo sapiens P53355
Pull Down
25619834
Intra
KLHL20 Q9Y2M5 CUL3 Homo sapiens Q13618
Anti Tag CoIP
20389280
Intra
KLHL20 Q9Y2M5 CUL3 Homo sapiens Q13618
Anti Tag CoIP
25619834
Intra
KLHL20 Q9Y2M5 CUL3 Homo sapiens Q13618
Anti Tag CoIP
33961781
Intra
KLHL20 Q9Y2M5 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 IVNS1ABP Homo sapiens Q9Y6Y0
Pull Down
25619834
Intra
KLHL20 Q9Y2M5 IVNS1ABP Homo sapiens Q9Y6Y0
Anti Bait CoIP
25619834
Intra
KLHL20 Q9Y2M5 IVNS1ABP Homo sapiens Q9Y6Y0
Anti Tag CoIP
25619834
Intra
KLHL20 Q9Y2M5 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 PHYH Homo sapiens O14832
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 DBH Homo sapiens P09172
Validated Y2H
32814053
Intra
KLHL20 Q9Y2M5 DBH Homo sapiens P09172
Y2H Array
32814053
Intra
KLHL20 Q9Y2M5 DBH Homo sapiens P09172
Y2H Pooling
32814053
Intra
KLHL20 Q9Y2M5 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
Intra
KLHL20 Q9Y2M5 PRMT6 Homo sapiens Q96LA8
Anti Tag CoIP
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

KLHL20 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89653 KLHL20 Antibody (YA8997) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Anterior Segment Dysgenesis 5

  • Anterior Segment Dysgenesis 5, Multiple Subtypes

  • ASGD5

  • Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-172563A BTR2000 TFA 98.95% Unkown
HY-172562 BTR2004 Inhibitor 99.86% Unkown
HY-172564 BTR2000-Gly-Gly-Gly / Unkown
HY-172564A BTR2000-Gly-Gly-Gly TFA 99.26% Unkown
HY-172563 BTR2000 / Unkown
HY-RS07362 KLHL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KLHL20 VGNC VGNC:30649
Macaca mulatta KLHL20 VGNC VGNC:74120
Felis catus KLHL20 VGNC VGNC:81199
Mus musculus KLHL20 MGD MGI:2444855
Canis familiaris KLHL20 VGNC VGNC:42455
Rattus norvegicus KLHL20 RGD RGD:1309490
Others KLHL20 NCBI