BTR2000-Gly-Gly-Gly TFA

Name: BTR2000-Gly-Gly-Gly TFA
Brand: MedChemExpress
SKU: HY-172564A
Rating: 4.5 (0 reviews)

Cat. No.: HY-172564A Purity: 99.26%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

BTR2000-Gly-Gly-Gly TFA is a E3 ligase ligand-linker conjugate (KLHL20) that can be used for the synthesis of PROTAC BTR2004 (HY-172562).

For research use only. We do not sell to patients.

BTR2000-Gly-Gly-Gly TFA Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of BTR2000-Gly-Gly-Gly TFA:

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•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

BTR2000-Gly-Gly-Gly TFA is a E3 ligase ligand-linker conjugate (KLHL20) that can be used for the synthesis of PROTAC BTR2004 (HY-172562)^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

935.99

Formula

C₃₇H₅₂F₃N₉O₁₂S₂

Appearance

Solid

Color

White to off-white

SMILES

NCC(NCC(NCC(N[C@H](C(N1[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CSC2)=O)=O)=O)CCC1)=O)CSCC3=CC=CC2=C3)=O)=O)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (106.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0684 mL	5.3419 mL	10.6839 mL
5 mM	0.2137 mL	1.0684 mL	2.1368 mL
10 mM	0.1068 mL	0.5342 mL	1.0684 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.26%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (260 KB) RP-HPLC (113 KB) MS (216 KB) Elemental Analysis Report (119 KB)

Handling Instructions (2659 KB)

References

[1]. Phoebe H Fechtmeyer, et al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv [Preprint]. 2024 Dec 7:2024.12.07.627262. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0684 mL	5.3419 mL	10.6839 mL	26.7097 mL
	5 mM	0.2137 mL	1.0684 mL	2.1368 mL	5.3419 mL
	10 mM	0.1068 mL	0.5342 mL	1.0684 mL	2.6710 mL
	15 mM	0.0712 mL	0.3561 mL	0.7123 mL	1.7806 mL
	20 mM	0.0534 mL	0.2671 mL	0.5342 mL	1.3355 mL
	25 mM	0.0427 mL	0.2137 mL	0.4274 mL	1.0684 mL
	30 mM	0.0356 mL	0.1781 mL	0.3561 mL	0.8903 mL
	40 mM	0.0267 mL	0.1335 mL	0.2671 mL	0.6677 mL
	50 mM	0.0214 mL	0.1068 mL	0.2137 mL	0.5342 mL
	60 mM	0.0178 mL	0.0890 mL	0.1781 mL	0.4452 mL
	80 mM	0.0134 mL	0.0668 mL	0.1335 mL	0.3339 mL
	100 mM	0.0107 mL	0.0534 mL	0.1068 mL	0.2671 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.