2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. BTR2004

BTR2004 is a selective BET family (BRD2/3/4) protein PROTAC degrader. BTR2004 forms a ternary complex with BRD proteins and KLHL20, inducing ubiquitination and proteasomal degradation through the UPS pathway. BTR2004 is promising for research of PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.
(Pink: BET ligand (HY-161125); Blue: Ligands for E3 Ligase ligand (HY-172563); Black: linker (HY-W015236)).

For research use only. We do not sell to patients.

BTR2004

BTR2004 Chemical Structure

CAS No. : 3093583-69-5

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BTR2004 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Epigenetic Reader Domain Isoform Specific Products:

View All Isoforms
Brd BRPF1 BRPF2 BRPF3 BRD2 BRD3 BRD4 BRDT CECR2 BD1 BD2 BRD7 BRD9 BET BAZ

  • Biological Activity

  • Purity & Documentation

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Description

BTR2004 is a selective BET family (BRD2/3/4) protein PROTAC degrader. BTR2004 forms a ternary complex with BRD proteins and KLHL20, inducing ubiquitination and proteasomal degradation through the UPS pathway. BTR2004 is promising for research of PC3 prostate cancer and MDA-MB-231 breast cancer cell lines[1][2]. (Pink: BET ligand (HY-161125); Blue: Ligands for E3 Ligase ligand (HY-172563); Black: linker (HY-W015236)).

Molecular Weight

1204.83

Formula

C54H66ClN13O11S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCC(NCC(NCC(N[C@H](C(N5[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CSC6)=O)=O)=O)CCC5)=O)CSCC7=CC=CC6=C7)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (83.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8300 mL 4.1500 mL 8.2999 mL
5 mM 0.1660 mL 0.8300 mL 1.6600 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8300 mL 4.1500 mL 8.2999 mL 20.7498 mL
5 mM 0.1660 mL 0.8300 mL 1.6600 mL 4.1500 mL
10 mM 0.0830 mL 0.4150 mL 0.8300 mL 2.0750 mL
15 mM 0.0553 mL 0.2767 mL 0.5533 mL 1.3833 mL
20 mM 0.0415 mL 0.2075 mL 0.4150 mL 1.0375 mL
25 mM 0.0332 mL 0.1660 mL 0.3320 mL 0.8300 mL
30 mM 0.0277 mL 0.1383 mL 0.2767 mL 0.6917 mL
40 mM 0.0207 mL 0.1037 mL 0.2075 mL 0.5187 mL
50 mM 0.0166 mL 0.0830 mL 0.1660 mL 0.4150 mL
60 mM 0.0138 mL 0.0692 mL 0.1383 mL 0.3458 mL
80 mM 0.0104 mL 0.0519 mL 0.1037 mL 0.2594 mL
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BTR2004 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTR20043093583-69-5BTR 2004BTR-2004PROTACsEpigenetic Reader DomainBRD2/3/4PC3 prostate cancer and MDA-MB-231 breast cancerInhibitorinhibitorinhibit

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