BTR2000
BTR2000, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562).
For research use only. We do not sell to patients.
- Formula: C29H42N6O7S2
- Molecular Weight:650.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 650.81
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Formula C29H42N6O7S2
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SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSCC3=CC=CC2=C3)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Farrell BM, et, al. A synthetic KLHL20 ligand to validate CUL3KLHL20 as a potent E3 ligase for targeted protein degradation. Genes Dev. 2022 Sep 1;36(17-18):1031-1042. [Content Brief]
[2]. Fechtmeyer PH, et, al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv. 2024 Dec 7:2024.12.07.627262. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTR2000 Related Classifications
HY-172563 Related Classifications
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