2. PROTAC
  3. Ligands for E3 Ligase
  4. BTR2000 TFA

BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 TFA can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562).

For research use only. We do not sell to patients.

BTR2000 TFA

BTR2000 TFA Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BTR2000 TFA:

BTR2000 TFA Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 TFA can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562)[1][2].

Molecular Weight

764.83

Formula

C31H43F3N6O9S2
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSCC3=CC=CC2=C3)N.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (81.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3075 mL 6.5374 mL 13.0748 mL
5 mM 0.2615 mL 1.3075 mL 2.6150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3075 mL 6.5374 mL 13.0748 mL 32.6870 mL
5 mM 0.2615 mL 1.3075 mL 2.6150 mL 6.5374 mL
10 mM 0.1307 mL 0.6537 mL 1.3075 mL 3.2687 mL
15 mM 0.0872 mL 0.4358 mL 0.8717 mL 2.1791 mL
20 mM 0.0654 mL 0.3269 mL 0.6537 mL 1.6344 mL
25 mM 0.0523 mL 0.2615 mL 0.5230 mL 1.3075 mL
30 mM 0.0436 mL 0.2179 mL 0.4358 mL 1.0896 mL
40 mM 0.0327 mL 0.1634 mL 0.3269 mL 0.8172 mL
50 mM 0.0261 mL 0.1307 mL 0.2615 mL 0.6537 mL
60 mM 0.0218 mL 0.1090 mL 0.2179 mL 0.5448 mL
80 mM 0.0163 mL 0.0817 mL 0.1634 mL 0.4086 mL
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BTR2000 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTR2000BTR 2000BTR-2000Ligands for E3 LigaseE3 ligase-recruiting MoietyKLHL20BTR2004Inhibitorinhibitorinhibit

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