BTR2000 TFA
Based on 1 Customer Validation
BTR2000 TFA, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 TFA can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562).
For research use only. We do not sell to patients.
- Purity: 98.95%
- Formula: C31H43F3N6O9S2
- Molecular Weight:764.83
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 764.83
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Formula C31H43F3N6O9S2
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Color White to off-white
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SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSCC3=CC=CC2=C3)N.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (81.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Farrell BM, et, al. A synthetic KLHL20 ligand to validate CUL3KLHL20 as a potent E3 ligase for targeted protein degradation. Genes Dev. 2022 Sep 1;36(17-18):1031-1042. [Content Brief]
[2]. Fechtmeyer PH, et, al. Temporal and Spatial Characterization of CUL3KLHL20-driven Targeted Degradation of BET family, BRD Proteins by the Macrocycle-based Degrader BTR2004. bioRxiv. 2024 Dec 7:2024.12.07.627262. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3075 mL | 6.5374 mL | 13.0748 mL | 32.6870 mL |
| 5 mM | 0.2615 mL | 1.3075 mL | 2.6150 mL | 6.5374 mL | |
| 10 mM | 0.1307 mL | 0.6537 mL | 1.3075 mL | 3.2687 mL | |
| 15 mM | 0.0872 mL | 0.4358 mL | 0.8717 mL | 2.1791 mL | |
| 20 mM | 0.0654 mL | 0.3269 mL | 0.6537 mL | 1.6344 mL | |
| 25 mM | 0.0523 mL | 0.2615 mL | 0.5230 mL | 1.3075 mL | |
| 30 mM | 0.0436 mL | 0.2179 mL | 0.4358 mL | 1.0896 mL | |
| 40 mM | 0.0327 mL | 0.1634 mL | 0.3269 mL | 0.8172 mL | |
| 50 mM | 0.0261 mL | 0.1307 mL | 0.2615 mL | 0.6537 mL | |
| 60 mM | 0.0218 mL | 0.1090 mL | 0.2179 mL | 0.5448 mL | |
| 80 mM | 0.0163 mL | 0.0817 mL | 0.1634 mL | 0.4086 mL |
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