BTR2038
BTR2038 is a BTR2000-based heterobifunctional PROTAC that induces the degradation of BRD9 by recruiting the CUL3KLHL20 E3 ubiquitin ligase. BTR2038 consists of a BRD9 bromodomain ligand derived from a BI-7273 analog, a linker, and the macrocyclic KLHL20 ligand BTR2000. BTR2038 is applicable for research related to KLHL20-recruited targeted protein degradation and BRD9 modulation.
(Pink: Target protein ligand; Blue: KLHL20 ligand (HY-172563); Black: linker).
For research use only. We do not sell to patients.
- Formula: C50H63N9O11S2
- Molecular Weight:1030.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
BTR2038 (10 μM; 4 h) reduces BRD9 protein levels in T-REx U2OS cells stably expressing V5-tagged human BRD9; the relative BRD9 gray values in two biological replicates are approximately 0.17 and 0.16, while the corresponding DMSO control values are approximately 0.85 and 1.00[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1030.22
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Formula C50H63N9O11S2
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SMILES
O=C(N1CCC[C@@H]1C(N[C@H](CC(O)=O)C(N[C@H](CC(C)C)C(N[C@@H](CSC2)C(N)=O)=O)=O)=O)[C@H](CSC3=CC2=CC=C3)NC(CCCNCC4=C(OC)C=C(C5=CN(C)C(C6=C5C=CN=C6)=O)C=C4OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTR2038 Related Classifications
HY-178043 Related Classifications
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