KLHL5 - kelch like family member 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51088

Summary

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in microtubule Cytoskeleton. Implicated in cocaine dependence. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in fat (RPKM 8.4), urinary bladder (RPKM 6.6) and 24 other tissues.

KLHL5 Products (4)

mRNA Protein Name
NM_001007075.2 NP_001007076.1 kelch-like protein 5 isoform 1
NM_001171654.1 NP_001165125.1 kelch-like protein 5 isoform 4
NM_015990.5 NP_057074.4 kelch-like protein 5 isoform 1
NM_199039.4 NP_950240.3 kelch-like protein 5 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHL5 Q96PQ7 CUL3 Homo sapiens Q13618
Anti Tag CoIP
31652307
Intra
KLHL5 Q96PQ7 CUL3 Homo sapiens Q13618
Anti Tag CoIP
30190310
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103060 KLH45 Inhibitor 99.81% Unkown
HY-RS07367 KLHL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07354 KLHL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07355 KLHL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07356 KLHL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07357 KLHL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07358 KLHL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07359 KLHL15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07360 KLHL17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07361 KLHL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07362 KLHL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07363 KLHL22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07364 KLHL24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07365 KLHL29 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07366 KLHL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07368 KLHL40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07369 KLHL41 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07370 KLHL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07371 KLHL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07372 KLHL9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182927 KLHL12 ligand-1 / Unkown
HY-RS20437 Klhl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21878 Klhl24 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22601 Klhl6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26946 Klhl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28395 Klhl24 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown