2433765-51-4
Chemical Structure
MK-1088
- CAS No.: 2433765-51-4
- Formula:C23H29FN8O2
- Molecular Weight:468.53
InChIKey: KIDBCXKFCAFVPL-UONOGXRCSA-N
SMILES: NC1=NC2=C(C=C(C(OC)=C2)F)C3=NC([C@@H]4CC[C@@H](N(C4)C5=CN(N=C5)CC(O)(C)C)C)=NN31
Biological Activity: MK-1088 is an orally active A2A/A2B adenosine receptor antagonist with human A2A Ki of 0.31 nM, human A2B Ki 5.3 nM. MK-1088 blocks receptor downstream signaling, inhibits CREB phosphorylation and reverses adenosine-mediated immunosuppression. MK-1088 restores TNF−α release and enhances tumor immune surveillance. MK-1088 can be used for the research of cancer[1].
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MK-1088 | MK-1088 is an orally active A2A/A2B adenosine receptor antagonist with human A2A Ki of 0.31 nM, human A2B Ki 5.3 nM. MK-1088 blocks receptor downstream signaling, inhibits CREB phosphorylation and reverses adenosine-mediated immunosuppression. MK-1088 restores TNF−α release and enhances tumor immune surveillance. MK-1088 can be used for the research of cancer. | |||||||||||||||||||||
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Keywords
