CUL2 - cullin 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8453

About CUL2

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,008,551-35,127,006 (from NCBI)

This gene has 49 transcripts (splice variants), 226 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL2 Products (6)

mRNA	Protein	Name
NM_001198777.2	NP_001185706.1	cullin-2 isoform c
NM_001198778.2	NP_001185707.1	cullin-2 isoform a
NM_001198779.1	NP_001185708.1	cullin-2 isoform b
NM_001324375.2	NP_001311304.1	cullin-2 isoform d
NM_001324376.2	NP_001311305.1	cullin-2 isoform e
NM_003591.4	NP_003582.2	cullin-2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12504026	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	29779948	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	17636018	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	29779948	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL2 Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
745 a.a.

Protein Preferred Names	Protein Names
cullin-2	CUL-2

CUL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CUL2	Q13617	KLHDC3	Homo sapiens	Q9BQ90	TAP	21145461
Intra	CUL2	Q13617	KLHDC3	Homo sapiens	Q9BQ90	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	COMMD1	Homo sapiens	Q8N668	Pull Down	23563313
Intra	CUL2	Q13617	COMMD1	Homo sapiens	Q8N668	Anti Bait CoIP	17183367
Intra	CUL2	Q13617	ZYG11B	Homo sapiens	Q9C0D3	TAP	21145461
Intra	CUL2	Q13617	ZYG11B	Homo sapiens	Q9C0D3	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	UBXN7	Homo sapiens	O94888	TAP	21145461
Intra	CUL2	Q13617	UBXN7	Homo sapiens	O94888	Anti Tag CoIP	22466964
Intra	CUL2	Q13617	LRRC14	Homo sapiens	Q15048	TAP	21145461
Intra	CUL2	Q13617	LRRC14	Homo sapiens	Q15048	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	15601820
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	Pull Down	23563313
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	Pull Down	19327355
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	TAP	21145461
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	GMS	25661653
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	TAP	21145461
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Anti Tag CoIP	18323857
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Anti Tag CoIP	15601820
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Ion Exchange Chrom	25661653
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	X-Ray Diffraction	25661653
Intra	CUL2	Q13617	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL2	Q13617	RBX1	Homo sapiens	P62877	Pull Down	19327355
Intra	CUL2	Q13617	RBX1	Homo sapiens	P62877	Anti Tag CoIP	15601820
Intra	CUL2	Q13617	CAND1	Homo sapiens	Q86VP6	Anti Bait CoIP	12504026
Cross	CUL2	Q13617	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

CUL2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82457	Cullin 2 Antibody (YA2202)	WB, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Moyamoya Angiopathy
External Ear Squamous Cell Carcinoma	Epidermoid Carcinoma Of The External Ear Squamous Cell Carcinoma Of External Ear
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
External Ear Carcinoma	Carcinoma Of External Ear Carcinoma Of The External Ear
Retinal Hemangioblastoma	Capillary Hemangioma Of Retina
Familial Renal Papillary Carcinoma	Hereditary Papillary Renal Carcinoma Papillary Renal Cancer Hereditary
Leiomyoma Cutis	Cutaneous Leiomyoma Leiomyoma Of The Skin
Dermis Tumor	Dermis Tumour Neoplasm Of Dermis Tumor Of Dermis Tumour Of Dermis
Hereditary Renal Cell Carcinoma
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Erythrocytosis, Familial, 2	Chuvash Polycythemia ECYT2 Familial Erythrocytosis 2 Autosomal Recessive Benign Erythrocytosis Polycythemia, Vhl-Dependent Chuvash Erythromatosis Chuvash Type Polycythemia Chuvash Erythrocytosis Von Hippel-Lindau-Dependent Polycythemia Polycythemia Chuvash Type Vhl-Dependent Polycythemia Erythrocytosis, Familial, Type 2
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Cardiovascular Organ Benign Neoplasm
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03360	CUL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20263	Cul2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26771	Cul2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CUL2	VGNC	VGNC:71566
Rattus norvegicus	CUL2	RGD	RGD:1310644
Canis familiaris	CUL2	VGNC	VGNC:39729
Mus musculus	CUL2	MGD	MGI:1918995
Bos taurus	CUL2	VGNC	VGNC:27830
Felis catus	CUL2	VGNC	VGNC:61283
Others	CUL2	NCBI