KLHDC3 - kelch domain containing 3 Gene

Also Known as PEAS; dJ20C7.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116138

About KLHDC3

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,014,249-43,021,294 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 10 paralogues. Broad expression in testis (RPKM 98.0), brain (RPKM 70.2) and 25 other tissues.

Summary

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]

KLHDC3 Products (1)

mRNA	Protein	Name
NM_057161.4	NP_476502.1	kelch domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	12606021	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12482870	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	26138980	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	26138980	GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	29779948	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	26138980	GOA
located in chromatin	IDA IDA: Inferred from direct assay	12606021	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12606021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHDC3 Protein Structure

Kelch_6

Kelch_4

Kelch_2

Kelch_6

0
100
200
300
382 a.a.

Protein Preferred Names	Protein Names
kelch domain-containing protein 3	testis intracellular mediator protein

KLHDC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KLHDC3	Q9BQ90	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	33961781
Intra	KLHDC3	Q9BQ90	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	28514442
Intra	KLHDC3	Q9BQ90	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	21145461
Intra	KLHDC3	Q9BQ90	CUL2	Homo sapiens	Q13617	TAP	21145461

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Noonan Syndrome 6	NS6 Noonan Syndrome, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177783	iDeg-1	Degrader	/	Unkown
HY-RS07349	KLHDC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLHDC3	VGNC	VGNC:74091
Felis catus	KLHDC3	VGNC	VGNC:63137
Bos taurus	KLHDC3	VGNC	VGNC:30636
Mus musculus	KLHDC3	MGD	MGI:2651568
Rattus norvegicus	KLHDC3	RGD	RGD:1307105
Others	KLHDC3	NCBI