DELE1 - DAP3 binding cell death enhancer 1 Gene

Also Known as DELE; DELE1(L); KIAA0141

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9812

About DELE1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,923,871-141,942,047 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 16.6), spleen (RPKM 16.6) and 25 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in HRI-mediated signaling; extrinsic apoptotic signaling pathway via death domain receptors; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

DELE1 Products (2)

mRNA	Protein	Name
NM_001142603.3	NP_001136075.1	death ligand signal enhancer precursor
NM_014773.5	NP_055588.3	death ligand signal enhancer precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20563667	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	32132706	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	32132706	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	37832546	GOA
involved in HRI-mediated signaling	IDA IDA: Inferred from direct assay	32132706	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	32132706	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	20563667	GOA
involved in integrated stress response signaling	IDA IDA: Inferred from direct assay	32132706	GOA
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	38340717	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	37550454	GOA
involved in response to iron ion starvation	IDA IDA: Inferred from direct assay	37327776	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	32132706	GOA
located in cytosol	IDA IDA: Inferred from direct assay	32132706	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	32132707	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	37327776	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DELE1 Protein Structure

Sel1

0
100
200
300
400
515 a.a.

Protein Preferred Names	Protein Names
death ligand signal enhancer	DAP3-binding cell death enhancer 1, long form

DELE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DELE1	Q14154	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	DELE1	Q14154	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	DELE1	Q14154	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	DELE1	Q14154	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	DELE1	Q14154	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	DELE1	Q14154	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	DELE1	Q14154	LSAMP	Homo sapiens	Q13449	Validated Y2H	32814053
Intra	DELE1	Q14154	LSAMP	Homo sapiens	Q13449	Y2H Pooling	32814053
Intra	DELE1	Q14154	LSAMP	Homo sapiens	Q13449	Y2H Array	32814053
Intra	DELE1	Q14154	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	DELE1	Q14154	CRX	Homo sapiens	O43186	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pulmonary Adenocarcinoma In Situ	Bronchioalveolar Carcinoma
Lung Carcinoma In Situ

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03684	DELE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DELE1	MGD	MGI:1914089
Rattus norvegicus	DELE1	RGD	RGD:735029
Bos taurus	DELE1	VGNC	VGNC:50135
Macaca mulatta	DELE1	VGNC	VGNC:71806
Felis catus	DELE1	VGNC	VGNC:61431
Canis familiaris	DELE1	VGNC	VGNC:53268
Others	DELE1	NCBI