GYS1 - glycogen synthase 1 Gene
Also Known as GSY; GYS
Species: Homo sapiens
About GYS1
This gene has 7 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 40.6), fat (RPKM 17.3) and 23 other tissues.
Summary
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
GYS1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001161587.2 | NP_001155059.1 | glycogen [starch] synthase, muscle isoform 2 |
| NM_002103.5 | NP_002094.2 | glycogen [starch] synthase, muscle isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity |
EXP
EXP: Inferred from Experiment
|
19699667 | GOA |
| enables glycogen synthase activity, transferring glucose-1-phosphate |
EXP
EXP: Inferred from Experiment
|
21356517 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10481074 | GOA |
GYS1 Protein Structure
Glycogen_syn: Glycogen synthase (31 - 662)
- 0
- 200
- 400
- 600
- 737 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glycogen [starch] synthase, muscle |
|
GYS1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GYS1 | P13807 | PNMA5 | Homo sapiens | Q96PV4 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PNMA5 | Homo sapiens | Q96PV4 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PNMA5 | Homo sapiens | Q96PV4 | 32296183 | |
|
Intra
|
GYS1 | P13807 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | BEND7 | Homo sapiens | Q8N7W2-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF774 | Homo sapiens | Q6NX45 | 32296183 | |
|
Intra
|
GYS1 | P13807 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | TLE5 | Homo sapiens | Q08117-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | TFAP2D | Homo sapiens | Q7Z6R9 | 32296183 | |
|
Intra
|
GYS1 | P13807 | GYG1 | Homo sapiens | P46976-2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CLVS2 | Homo sapiens | Q5SYC1 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CLVS2 | Homo sapiens | Q5SYC1 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CLVS2 | Homo sapiens | Q5SYC1 | 32296183 | |
|
Intra
|
GYS1 | P13807 | NDUFB7 | Homo sapiens | P17568 | 32296183 | |
|
Intra
|
GYS1 | P13807 | NDUFB7 | Homo sapiens | P17568 | 32296183 | |
|
Intra
|
GYS1 | P13807 | NDUFB7 | Homo sapiens | P17568 | 32296183 | |
|
Intra
|
GYS1 | P13807 | FAM228A | Homo sapiens | Q86W67 | 32296183 | |
|
Intra
|
GYS1 | P13807 | FAM228A | Homo sapiens | Q86W67 | 32296183 | |
|
Intra
|
GYS1 | P13807 | FAM228A | Homo sapiens | Q86W67 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF212 | Homo sapiens | Q9UDV6 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF212 | Homo sapiens | Q9UDV6 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF212 | Homo sapiens | Q9UDV6 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF474 | Homo sapiens | Q6S9Z5 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF474 | Homo sapiens | Q6S9Z5 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF474 | Homo sapiens | Q6S9Z5 | 32296183 | |
|
Intra
|
GYS1 | P13807 | HOXC8 | Homo sapiens | P31273 | 32296183 | |
|
Intra
|
GYS1 | P13807 | EFHC2 | Homo sapiens | Q5JST6 | 32296183 | |
|
Intra
|
GYS1 | P13807 | EFHC2 | Homo sapiens | Q5JST6 | 32296183 | |
|
Intra
|
GYS1 | P13807 | EFHC2 | Homo sapiens | Q5JST6 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZBTB33 | Homo sapiens | Q86T24 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZBTB33 | Homo sapiens | Q86T24 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZBTB33 | Homo sapiens | Q86T24 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF552 | Homo sapiens | Q9H707 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF326 | Homo sapiens | Q5BKZ1 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF326 | Homo sapiens | Q5BKZ1 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF326 | Homo sapiens | Q5BKZ1 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PCYT1A | Homo sapiens | P49585 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PCYT1A | Homo sapiens | P49585 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PCYT1A | Homo sapiens | P49585 | 32296183 | |
|
Intra
|
GYS1 | P13807 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
GYS1 | P13807 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
GYS1 | P13807 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PLAGL2 | Homo sapiens | Q9UPG8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PLAGL2 | Homo sapiens | Q9UPG8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PLAGL2 | Homo sapiens | Q9UPG8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | GSK3B | Homo sapiens | P49841 | 24165324 | |
|
Intra
|
GYS1 | P13807 | ZNF620 | Homo sapiens | Q6ZNG0 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF620 | Homo sapiens | Q6ZNG0 | 32296183 | |
|
Intra
|
GYS1 | P13807 | ZNF620 | Homo sapiens | Q6ZNG0 | 32296183 | |
|
Intra
|
GYS1 | P13807 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
GYS1 | P13807 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
GYS1 | P13807 | RBM48 | Homo sapiens | Q5RL73 | 32296183 | |
|
Intra
|
GYS1 | P13807 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
GYS1 | P13807 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
GYS1 | P13807 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KATNBL1 | Homo sapiens | Q9H079 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KATNBL1 | Homo sapiens | Q9H079 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KATNBL1 | Homo sapiens | Q9H079 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PINX1 | Homo sapiens | Q96BK5 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PINX1 | Homo sapiens | Q96BK5 | 32296183 | |
|
Intra
|
GYS1 | P13807 | PINX1 | Homo sapiens | Q96BK5 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KLF4 | Homo sapiens | O43474 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KLF4 | Homo sapiens | O43474 | 32296183 | |
|
Intra
|
GYS1 | P13807 | GYG1 | Homo sapiens | P46976 | 17055998 | |
|
Intra
|
GYS1 | P13807 | GYG1 | Homo sapiens | P46976 | 25416956 | |
|
Intra
|
GYS1 | P13807 | GYG1 | Homo sapiens | P46976 | 25416956 | |
|
Intra
|
GYS1 | P13807 | GYG1 | Homo sapiens | P46976 | 17055998 | |
|
Intra
|
GYS1 | P13807 | GYG1 | Homo sapiens | P46976 | 35271311 | |
|
Intra
|
GYS1 | P13807 | SORBS3 | Homo sapiens | O60504 | 32296183 | |
|
Intra
|
GYS1 | P13807 | SORBS3 | Homo sapiens | O60504 | 32296183 | |
|
Intra
|
GYS1 | P13807 | HOXB6 | Homo sapiens | P17509 | 32296183 | |
|
Intra
|
GYS1 | P13807 | HOXB6 | Homo sapiens | P17509 | 32296183 | |
|
Intra
|
GYS1 | P13807 | HOXB6 | Homo sapiens | P17509 | 32296183 | |
|
Intra
|
GYS1 | P13807 | AIMP2 | Homo sapiens | Q13155 | 25416956 | |
|
Intra
|
GYS1 | P13807 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CRX | Homo sapiens | O43186 | 32296183 | |
|
Intra
|
GYS1 | P13807 | SNIP1 | Homo sapiens | Q8TAD8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | SNIP1 | Homo sapiens | Q8TAD8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | SNIP1 | Homo sapiens | Q8TAD8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | GYG2 | Homo sapiens | O15488 | 35271311 | |
|
Intra
|
GYS1 | P13807 | GYG2 | Homo sapiens | O15488 | 16189514 | |
|
Intra
|
GYS1 | P13807 | KLF1 | Homo sapiens | Q13351 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KLF1 | Homo sapiens | Q13351 | 32296183 | |
|
Intra
|
GYS1 | P13807 | KLF1 | Homo sapiens | Q13351 | 32296183 | |
|
Intra
|
GYS1 | P13807 | IHO1 | Homo sapiens | Q8IYA8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | IHO1 | Homo sapiens | Q8IYA8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | IHO1 | Homo sapiens | Q8IYA8 | 25416956 | |
|
Intra
|
GYS1 | P13807 | IHO1 | Homo sapiens | Q8IYA8 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CDCA8 | Homo sapiens | Q53HL2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CDCA8 | Homo sapiens | Q53HL2 | 32296183 | |
|
Intra
|
GYS1 | P13807 | CDCA8 | Homo sapiens | Q53HL2 | 32296183 |
GYS1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80145 | Glycogen synthase 1/GYS1 Antibody (YA400) | WB, ICC/IF, IHC-P, FC, IP | Human, Mouse |
| HY-P80277 | Phospho-Glycogen synthase 1/GYS1 (S641) Antibody (YA195) | WB, ICC/IF, IHC-P, IP | Human, Mouse, Rat |
| HY-P80694 | Glycogen synthase 1/GYS1 Antibody (YA401) | WB, ICC/IF, IP | Human, Rat |
| HY-P80694A | Glycogen synthase 1/GYS1 Antibody (YA401)(PBS only) | WB, ICC/IF, IP | Human, Rat |
| HY-P84093 | Glycogen synthase 1/GYS1 Antibody (YA3790) | WB, FC, ELISA | Human |
| HY-P84093A | Glycogen synthase 1/GYS1 Antibody (YA3790)(PBS only) | WB, FC, ELISA | Human |
| HY-P85189 | Glycogen synthase 1/GYS1 Antibody (YA4881) | WB, FC, ELISA | Human |
| HY-P86333 | Glycogen synthase 1/GYS1 Antibody (YA6025) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Glycogen Storage Disease 0, Muscle |
|
|
| Glycogen Storage Disease |
|
|
| Myoclonic Epilepsy Of Lafora |
|
|
| Hypoglycemia |
|
|
| Glycogen Storage Disease Type 0 |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Glucose Intolerance |
|
|
| Hyperglycemia |
|
|
| Glycogen Storage Disease Iii |
|
|
| Hyperinsulinism |
|
|
| Glycogen Storage Disease Vi |
|
|
| Progressive Myoclonus Epilepsy |
|
|
| Glycogen Storage Disease V |
|
|
| Epilepsy |
|
|
| Glycogen Storage Disease Ia |
|
|
| Diabetes Mellitus |
|
|
| Myopathy |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | GYS1 | VGNC | VGNC:41574 |
| Felis catus | GYS1 | VGNC | VGNC:67524 |
| Macaca mulatta | GYS1 | VGNC | VGNC:73334 |
| Mus musculus | GYS1 | MGD | MGI:101805 |
| Rattus norvegicus | GYS1 | RGD | RGD:1589798 |
| Bos taurus | GYS1 | VGNC | VGNC:29730 |
| Others | GYS1 | NCBI |