GYS1 - glycogen synthase 1 Gene

Also Known as GSY; GYS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2997

About GYS1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,968,130-48,993,309 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 40.6), fat (RPKM 17.3) and 23 other tissues.

Summary

The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GYS1 Products (2)

mRNA Protein Name
NM_001161587.2 NP_001155059.1 glycogen [starch] synthase, muscle isoform 2
NM_002103.5 NP_002094.2 glycogen [starch] synthase, muscle isoform 1
Molecular Function GO Annotation Evidence References Source
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity EXP
EXP: Inferred from Experiment
19699667 GOA
enables glycogen synthase activity, transferring glucose-1-phosphate EXP
EXP: Inferred from Experiment
21356517 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10481074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GYS1 Protein Structure

Glycogen_syn

Glycogen_syn: Glycogen synthase (31 - 662)

  • 0
  • 200
  • 400
  • 600
  • 737 a.a.
Protein Preferred Names Protein Names

glycogen [starch] synthase, muscle

  • glycogen synthase 1 (muscle)

GYS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GYS1 P13807 PNMA5 Homo sapiens Q96PV4 32296183
Intra
GYS1 P13807 PNMA5 Homo sapiens Q96PV4 32296183
Intra
GYS1 P13807 PNMA5 Homo sapiens Q96PV4 32296183
Intra
GYS1 P13807 BEND7 Homo sapiens Q8N7W2-2 32296183
Intra
GYS1 P13807 BEND7 Homo sapiens Q8N7W2-2 32296183
Intra
GYS1 P13807 BEND7 Homo sapiens Q8N7W2-2 32296183
Intra
GYS1 P13807 ZNF774 Homo sapiens Q6NX45 32296183
Intra
GYS1 P13807 ZNF774 Homo sapiens Q6NX45 32296183
Intra
GYS1 P13807 ZNF774 Homo sapiens Q6NX45 32296183
Intra
GYS1 P13807 TLE5 Homo sapiens Q08117-2 32296183
Intra
GYS1 P13807 TLE5 Homo sapiens Q08117-2 32296183
Intra
GYS1 P13807 TLE5 Homo sapiens Q08117-2 32296183
Intra
GYS1 P13807 TFAP2D Homo sapiens Q7Z6R9 32296183
Intra
GYS1 P13807 GYG1 Homo sapiens P46976-2 32296183
Intra
GYS1 P13807 CLVS2 Homo sapiens Q5SYC1 32296183
Intra
GYS1 P13807 CLVS2 Homo sapiens Q5SYC1 32296183
Intra
GYS1 P13807 CLVS2 Homo sapiens Q5SYC1 32296183
Intra
GYS1 P13807 NDUFB7 Homo sapiens P17568 32296183
Intra
GYS1 P13807 NDUFB7 Homo sapiens P17568 32296183
Intra
GYS1 P13807 NDUFB7 Homo sapiens P17568 32296183
Intra
GYS1 P13807 FAM228A Homo sapiens Q86W67 32296183
Intra
GYS1 P13807 FAM228A Homo sapiens Q86W67 32296183
Intra
GYS1 P13807 FAM228A Homo sapiens Q86W67 32296183
Intra
GYS1 P13807 ZNF212 Homo sapiens Q9UDV6 32296183
Intra
GYS1 P13807 ZNF212 Homo sapiens Q9UDV6 32296183
Intra
GYS1 P13807 ZNF212 Homo sapiens Q9UDV6 32296183
Intra
GYS1 P13807 ZNF474 Homo sapiens Q6S9Z5 32296183
Intra
GYS1 P13807 ZNF474 Homo sapiens Q6S9Z5 32296183
Intra
GYS1 P13807 ZNF474 Homo sapiens Q6S9Z5 32296183
Intra
GYS1 P13807 HOXC8 Homo sapiens P31273 32296183
Intra
GYS1 P13807 EFHC2 Homo sapiens Q5JST6 32296183
Intra
GYS1 P13807 EFHC2 Homo sapiens Q5JST6 32296183
Intra
GYS1 P13807 EFHC2 Homo sapiens Q5JST6 32296183
Intra
GYS1 P13807 ZBTB33 Homo sapiens Q86T24 32296183
Intra
GYS1 P13807 ZBTB33 Homo sapiens Q86T24 32296183
Intra
GYS1 P13807 ZBTB33 Homo sapiens Q86T24 32296183
Intra
GYS1 P13807 ZNF552 Homo sapiens Q9H707 32296183
Intra
GYS1 P13807 ZNF552 Homo sapiens Q9H707 32296183
Intra
GYS1 P13807 ZNF552 Homo sapiens Q9H707 32296183
Intra
GYS1 P13807 ZNF326 Homo sapiens Q5BKZ1 32296183
Intra
GYS1 P13807 ZNF326 Homo sapiens Q5BKZ1 32296183
Intra
GYS1 P13807 ZNF326 Homo sapiens Q5BKZ1 32296183
Intra
GYS1 P13807 PCYT1A Homo sapiens P49585 32296183
Intra
GYS1 P13807 PCYT1A Homo sapiens P49585 32296183
Intra
GYS1 P13807 PCYT1A Homo sapiens P49585 32296183
Intra
GYS1 P13807 MEOX1 Homo sapiens P50221 32296183
Intra
GYS1 P13807 MEOX1 Homo sapiens P50221 32296183
Intra
GYS1 P13807 MEOX1 Homo sapiens P50221 32296183
Intra
GYS1 P13807 PLAGL2 Homo sapiens Q9UPG8 32296183
Intra
GYS1 P13807 PLAGL2 Homo sapiens Q9UPG8 32296183
Intra
GYS1 P13807 PLAGL2 Homo sapiens Q9UPG8 32296183
Intra
GYS1 P13807 GSK3B Homo sapiens P49841 24165324
Intra
GYS1 P13807 ZNF620 Homo sapiens Q6ZNG0 32296183
Intra
GYS1 P13807 ZNF620 Homo sapiens Q6ZNG0 32296183
Intra
GYS1 P13807 ZNF620 Homo sapiens Q6ZNG0 32296183
Intra
GYS1 P13807 RBM48 Homo sapiens Q5RL73 32296183
Intra
GYS1 P13807 RBM48 Homo sapiens Q5RL73 32296183
Intra
GYS1 P13807 RBM48 Homo sapiens Q5RL73 32296183
Intra
GYS1 P13807 INCA1 Homo sapiens Q0VD86 32296183
Intra
GYS1 P13807 INCA1 Homo sapiens Q0VD86 32296183
Intra
GYS1 P13807 INCA1 Homo sapiens Q0VD86 32296183
Intra
GYS1 P13807 KATNBL1 Homo sapiens Q9H079 32296183
Intra
GYS1 P13807 KATNBL1 Homo sapiens Q9H079 32296183
Intra
GYS1 P13807 KATNBL1 Homo sapiens Q9H079 32296183
Intra
GYS1 P13807 PINX1 Homo sapiens Q96BK5 32296183
Intra
GYS1 P13807 PINX1 Homo sapiens Q96BK5 32296183
Intra
GYS1 P13807 PINX1 Homo sapiens Q96BK5 32296183
Intra
GYS1 P13807 KLF4 Homo sapiens O43474 32296183
Intra
GYS1 P13807 KLF4 Homo sapiens O43474 32296183
Intra
GYS1 P13807 GYG1 Homo sapiens P46976
Y2H
17055998
Intra
GYS1 P13807 GYG1 Homo sapiens P46976 25416956
Intra
GYS1 P13807 GYG1 Homo sapiens P46976 25416956
Intra
GYS1 P13807 GYG1 Homo sapiens P46976 17055998
Intra
GYS1 P13807 GYG1 Homo sapiens P46976 35271311
Intra
GYS1 P13807 SORBS3 Homo sapiens O60504 32296183
Intra
GYS1 P13807 SORBS3 Homo sapiens O60504 32296183
Intra
GYS1 P13807 HOXB6 Homo sapiens P17509 32296183
Intra
GYS1 P13807 HOXB6 Homo sapiens P17509 32296183
Intra
GYS1 P13807 HOXB6 Homo sapiens P17509 32296183
Intra
GYS1 P13807 AIMP2 Homo sapiens Q13155 25416956
Intra
GYS1 P13807 CRX Homo sapiens O43186 32296183
Intra
GYS1 P13807 CRX Homo sapiens O43186 32296183
Intra
GYS1 P13807 SNIP1 Homo sapiens Q8TAD8 32296183
Intra
GYS1 P13807 SNIP1 Homo sapiens Q8TAD8 32296183
Intra
GYS1 P13807 SNIP1 Homo sapiens Q8TAD8 32296183
Intra
GYS1 P13807 GYG2 Homo sapiens O15488 35271311
Intra
GYS1 P13807 GYG2 Homo sapiens O15488 16189514
Intra
GYS1 P13807 KLF1 Homo sapiens Q13351 32296183
Intra
GYS1 P13807 KLF1 Homo sapiens Q13351 32296183
Intra
GYS1 P13807 KLF1 Homo sapiens Q13351 32296183
Intra
GYS1 P13807 IHO1 Homo sapiens Q8IYA8 32296183
Intra
GYS1 P13807 IHO1 Homo sapiens Q8IYA8 32296183
Intra
GYS1 P13807 IHO1 Homo sapiens Q8IYA8 25416956
Intra
GYS1 P13807 IHO1 Homo sapiens Q8IYA8 32296183
Intra
GYS1 P13807 CDCA8 Homo sapiens Q53HL2 32296183
Intra
GYS1 P13807 CDCA8 Homo sapiens Q53HL2 32296183
Intra
GYS1 P13807 CDCA8 Homo sapiens Q53HL2 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

GYS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80145 Glycogen synthase 1/GYS1 Antibody (YA400) WB, ICC/IF, IHC-P, FC, IP Human, Mouse
HY-P80277 Phospho-Glycogen synthase 1/GYS1 (S641) Antibody (YA195) WB, ICC/IF, IHC-P, IP Human, Mouse, Rat
HY-P80694 Glycogen synthase 1/GYS1 Antibody (YA401) WB, ICC/IF, IP Human, Rat
HY-P80694A Glycogen synthase 1/GYS1 Antibody (YA401)(PBS only) WB, ICC/IF, IP Human, Rat
HY-P84093 Glycogen synthase 1/GYS1 Antibody (YA3790) WB, FC, ELISA Human
HY-P84093A Glycogen synthase 1/GYS1 Antibody (YA3790)(PBS only) WB, FC, ELISA Human
HY-P85189 Glycogen synthase 1/GYS1 Antibody (YA4881) WB, FC, ELISA Human
HY-P86333 Glycogen synthase 1/GYS1 Antibody (YA6025) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Glycogen Storage Disease 0, Muscle
  • Muscle Glycogen Synthase Deficiency

  • Glycogen Storage Disease Due To Muscle And Heart Glycogen Synthase Deficiency

  • GSD0B

  • Muscle Glycogen Storage Disease 0

  • Gsd 0b

  • Glycogen Storage Disease Type 0, Muscle

  • Gsd Due To Muscle And Heart Glycogen Synthase Deficiency

  • Gsd Type 0b

  • Glycogen Storage Disease Type 0b

  • Glycogenosis Due To Muscle And Heart Glycogen Synthase Deficiency

  • Glycogenosis Type 0b

  • Storage Disease, Glycogen, Type 0, Muscle

Glycogen Storage Disease
  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency

Myoclonic Epilepsy Of Lafora
  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora

Hypoglycemia
  • Hypoglycaemia

  • Low Blood Sugar

  • Hypoglycaemia Nos

  • Spontaneous Hypoglycaemia

  • Nondiabetic Hypoglycaemia

  • Hypoglycaemic Disorder Nos

  • Hypoglycaemic Syndrome

Glycogen Storage Disease Type 0
  • Glycogen Synthase Deficiency

  • Glycogen Storage Disease 0

  • Glycogen Synthetase Deficiency

  • Gsd 0

  • Gsd Type 0

  • Hypoglycemia With Deficiency Of Glycogen Synthetase

Type 2 Diabetes Mellitus
  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes

Glucose Intolerance
  • Glucose: Intolerance

  • Glucose: Malabsorption

  • Malabsorption Of Glucose

  • Impaired Glucose Tolerance

Hyperglycemia
Glycogen Storage Disease Iii
  • Glycogen Storage Disease Type Iii

  • Forbes Disease

  • Cori Disease

  • Glycogen Storage Disease Iiia

  • Amylo-1,6-Glucosidase Deficiency

  • Glycogen Storage Disease Iiib

  • Limit Dextrinosis

  • GSD3

  • Agl Deficiency

  • Glycogen Debrancher Deficiency

  • Gde Deficiency

  • Glycogen Storage Disease Iiic

  • Debrancher Deficiency

  • Glycogen Storage Disease Type 3

  • Glycogenosis Type Iii

  • Glycogen Storage Disease Iiid

  • Amylo 1,6 Glucosidase Deficiency

  • Deficiency Of Debranching Enzyme

  • Deficiency Of Dextrin

  • Glycogen Storage Disease, Type Iii

  • Glycogen Debranching Enzyme Deficiency

  • Cori'S Disease

  • Gsd Iii

  • Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency

  • Cori-Forbes Disease

  • Gsd Due To Glycogen Debranching Enzyme Deficiency

  • Gsd Type 3

  • Gsdiii

  • Glycogenosis Due To Glycogen Debranching Enzyme Deficiency

  • Glycogenosis Type 3

  • Glycogen Storage Disease 3

  • Glycogen Debranching Enzyme Deficiency

  • Gsd-Iii

  • Gsd Iiia

  • Gsd Iiib

  • Gsd Iiic

  • Gsd Iiid

  • Storage Disease, Glycogen, Type Iii

Hyperinsulinism
  • Hyperinsulinemia

Glycogen Storage Disease Vi
  • Glycogen Storage Disease Type Vi

  • Hers Disease

  • GSD6

  • Gsd Vi

  • Hepatic Glycogen Phosphorylase Deficiency

  • Phosphorylase Deficiency Glycogen-Storage Disease Of Liver

  • Hers' Disease

  • Glycogen Storage Disease Type 6

  • Glycogen Storage Disease 6

  • Gsd Type Vi

  • Glycogenosis Type Vi

  • Glycogen Storage Disease, Type Vi

  • Hepatophosphorylase Deficiency Glycogenosis

  • Liver Phosphorylase Deficiency Syndrome

  • Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Type 6

  • Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency

  • Glycogenosis Type 6

  • Hepatic Phosphorylase Deficiency

  • Liver Glycogen Phosphorylase Deficiency

  • Her

  • Glycogen Storage Disease Vib

  • Gsd-Vi

  • Liver Phosphorylase Deficiency

  • Storage Disease, Glycogen, Type Vi

Progressive Myoclonus Epilepsy
  • Pme

  • Progressive Myoclonic Epilepsy

  • Myoclonic Epilepsies, Progressive

  • Unverricht-Lundborg Syndrome

Glycogen Storage Disease V
  • Mcardle Disease

  • Myophosphorylase Deficiency

  • Glycogen Storage Disease Type V

  • Muscle Glycogen Phosphorylase Deficiency

  • Pygm Deficiency

  • Gsd V

  • Glycogen Storage Disease, Type V

  • Glycogenosis Type V

  • Glycogen Storage Disease Type 5

  • GSD5

  • Pygmy

  • Mcardle'S Disease

  • Mcardle Type Glycogen Storage Disease

  • Gsd Type V

  • Pygmy, African

  • Gsdv

  • Gsd 5

  • Glycogenosis 5

  • Mcardle Syndrome

  • Muscle Phosphorylase Deficiency

  • Glycogen Storage Disease Due To Muscle Glycogen Phosphorylase Deficiency

  • Gsd Due To Muscle Glycogen Phosphorylase Deficiency

  • Gsd Type 5

  • Glycogenosis Due To Muscle Glycogen Phosphorylase Deficiency

  • Glycogenosis Type 5

  • Glycogen Storage Disease 5

  • Gsd-V

  • Mcardles Disease

  • Storage Disease, Glycogen, Type V

Epilepsy
  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders

Glycogen Storage Disease Ia
  • Von Gierke Disease

  • Glycogen Storage Disease Type I

  • Glycogen Storage Disease I

  • Hepatorenal Form Of Glycogen Storage Disease

  • Hepatorenal Glycogenosis

  • Glucose-6-Phosphatase Deficiency

  • Glycogen Storage Disease, Type I

  • Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia

  • GSD1A

  • Gsd1

  • Von Gierke'S Disease

  • Glycogen Storage Disease Type 1a

  • Glycogen Storage Disease 1a

  • Glucose-6-Phosphate Transport Defect

  • Gsd Ia

  • Deficiency Of Glucose-6-Phosphatase

  • Glycogenosis Type I

  • Glucose-6-Phosphatase Deficiency Glycogen Storage Disease

  • Glycogenosis Type 1

  • Glucose-6-Phosphate Deficiency

  • Gsd I

  • Gsd Type I

  • G6p Deficiency Type 1a

  • Gsd Due To G6p Deficiency Type 1a

  • Gsd Due To G6p Deficiency Type Ia

  • Gsd Type 1a

  • Gsdia

  • Glycogen Storage Disease Due To G6p Deficiency Type Ia

  • Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a

  • Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia

  • Glycogenosis Type Ia

  • Gsd-Ia

  • Storage Disease, Glycogen, Type 1a

  • Glycogen Storage Disease Type Ia

Diabetes Mellitus
  • Diabetes

Myopathy
  • Muscular Diseases

  • Myopathies

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris GYS1 VGNC VGNC:41574
Felis catus GYS1 VGNC VGNC:67524
Macaca mulatta GYS1 VGNC VGNC:73334
Mus musculus GYS1 MGD MGI:101805
Rattus norvegicus GYS1 RGD RGD:1589798
Bos taurus GYS1 VGNC VGNC:29730
Others GYS1 NCBI