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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Glycogen synthase 1/GYS1 Antibody (YA401)

Glycogen synthase 1/GYS1 Antibody (YA401)

Cat. No.: HY-P80694
User Guide for Antibodies Technical Support

Glycogen synthase 1/GYS1 Antibody (YA401) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glycogen synthase 1/GYS1.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Glycogen synthase 1/GYS1 Antibody (YA401) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glycogen synthase 1/GYS1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 84 kDa;
Observed band size: 84 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Rat
SwissProt ID
Gene ID
Immunogen

Synthetic peptide corresponding to Human Glycogen synthase 1.The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Purity affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan
Expression：
Tissue_specificity:It is expressed in skeletal muscle and most other glycogen-containing cell types.
Isoforms & Post-Translational Modification：P13807 has 2 isomers: P13807-1: 83786 Da (predicted); P13807-2: 76483 Da (predicted).
Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (PubMed:35835870)
Subunit：Part of the GYS1-GYG1 complex, a heterooctamer composed of a tetramer of GYS1 and 2 dimers of GYG1, where each GYS1 protomer binds to one GYG1 subunit (via GYG1 C-terminus); the GYS1 tetramer may dissociate from GYG1 dimers to continue glycogen polymerization on its own
Database

Entrez Gene: 2997 Human ; 14936 Mouse ; 690987 Rat

SwissProt: P13807 Human ; Q9Z1E4 Mouse ; A2RRU1 Rat

OMIM: 611556 Human

Research Field

Signal Transduction
Synonyms
GYS1; GYS; Glycogen [starch] synthase; muscle
Documentation
User Guide for Antibodies (1077 KB)

Glycogen synthase 1/GYS1 Antibody (YA401) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Glycogen synthase 1/GYS1 Antibody (YA401)
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