ANXA11 - annexin A11 Gene

Homo sapiens

Also known as ALS23; ANX11; CAP50; CAP-50; IBMWMA

Gene ID: 311 | Gene type: protein coding

About ANXA11

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,150,889-80,205,808 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 36.2), heart (RPKM 32.2) and 25 other tissues.

Summary

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

ANXA11 Products(6)

mRNA	Protein	Name
NM_001157.3	NP_001148.1	annexin A11 isoform 1
NM_001278407.2	NP_001265336.1	annexin A11 isoform 1
NM_001278408.2	NP_001265337.1	annexin A11 isoform 1
NM_001278409.2	NP_001265338.1	annexin A11 isoform 2
NM_145868.2	NP_665875.1	annexin A11 isoform 1
NM_145869.2	NP_665876.1	annexin A11 isoform 1

ANXA11 Protein Structure

Annexin

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

annexin A11

56 kDa autoantigen

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 23

Amyotrophic Lateral Sclerosis Type 23

ALS23

Inclusion Body Myopathy And Brain White Matter Abnormalities

Multisystem Proteinopathy 6	IBMWMA
Msp6

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Uveoparotid Fever

Heerfordt'S Syndrome

Papillary Hidradenoma

Tubular Sweat Gland Adenomas

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00759	ANXA11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANXA11	VGNC	VGNC:37938
Macaca mulatta	ANXA11	VGNC	VGNC:69946
Rattus norvegicus	ANXA11	RGD	RGD:1309911
Mus musculus	ANXA11	MGD	MGI:108481
Felis catus	ANXA11	VGNC	VGNC:67689
Bos taurus	ANXA11	VGNC	VGNC:25964

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