ASCL3 - achaete-scute family bHLH transcription factor 3 Gene

Also Known as SGN1; HASH3; bHLHa42

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56676

About ASCL3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,937,578-8,943,016 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 4 paralogues. Biased expression in salivary gland (RPKM 1.2) and testis (RPKM 0.1).

Summary

Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]

ASCL3 Products (1)

mRNA Protein Name
NM_020646.3 NP_065697.1 achaete-scute homolog 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASCL3 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (97 - 146)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

achaete-scute homolog 3

  • achaete-scute complex homolog 3

ASCL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ASCL3 Q9NQ33 HEMK1 Homo sapiens Q9Y5R4
Validated Y2H
32296183
Intra
ASCL3 Q9NQ33 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
ASCL3 Q9NQ33 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
ASCL3 Q9NQ33 TCF3 Homo sapiens P15923-3
Y2H Prey Pooling
32296183
Intra
ASCL3 Q9NQ33 TCF3 Homo sapiens P15923-3
Y2H Array
32296183
Intra
ASCL3 Q9NQ33 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ASCL3 Q9NQ33 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ascaris Lumbricoides Infection

  • Ascariasis

  • Ascaris Lumbricoides Infection, Susceptibility To

  • Ascariasis, Susceptibility To

  • Ascariasis - Roundworm

  • Infection Due To Ascaris Lumbricoides

  • Ascaridiasis

  • Roundworm Infection

  • Ascaridia

  • Ascaridiosis

  • Ascaridosis

  • Ascariosis

  • Ascaris

  • Ascaris Lumbricoides Infestation

  • Ascaris Infection

  • Infection By Ascaridia
Anisakiasis

  • Infection By Anisakis Larva

  • Anisakis Infection

  • Pseudoterranova Infection

  • Anisakiasis Due To Anisakis Simplex

  • Anisakiasis Due To Pseudoterranova Decipiens

  • Anisakis Infestation

  • Infection Due To Anisakis Larvae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01080 ASCL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ASCL3 VGNC VGNC:54856
Canis familiaris ASCL3 VGNC VGNC:38175
Mus musculus ASCL3 MGD MGI:1928820
Felis catus ASCL3 VGNC VGNC:68333
Rattus norvegicus ASCL3 RGD RGD:621631
Macaca mulatta ASCL3 VGNC VGNC:70031
Others ASCL3 NCBI