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TUBGCP5 - tubulin gamma complex associated protein 5 Gene

Also Known as GCP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114791

About TUBGCP5

Cytogenetic location: 15q11.2 Genomic coordinates (GRCh38): 15:22,983,025-23,039,569 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 205 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]

TUBGCP5 Products (9)

mRNA	Protein	Name
NM_001102610.2	NP_001096080.1	gamma-tubulin complex component 5 isoform b
NM_001354372.2	NP_001341301.1	gamma-tubulin complex component 5 isoform c
NM_001354373.2	NP_001341302.1	gamma-tubulin complex component 5 isoform d
NM_001354374.2	NP_001341303.1	gamma-tubulin complex component 5 isoform e
NM_001354375.2	NP_001341304.1	gamma-tubulin complex component 5 isoform f
NM_001354376.2	NP_001341305.1	gamma-tubulin complex component 5 isoform g
NM_001354377.2	NP_001341306.1	gamma-tubulin complex component 5 isoform h
NM_001354378.2	NP_001341307.1	gamma-tubulin complex component 5 isoform i
NM_052903.6	NP_443135.3	gamma-tubulin complex component 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	11694571	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in microtubule nucleation	IDA IDA: Inferred from direct assay	11694571	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
part of gamma-tubulin ring complex	IDA IDA: Inferred from direct assay	11694571	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUBGCP5 Protein Structure

Spc97_Spc98

0
200
400
600
800
1024 a.a.

Protein Preferred Names	Protein Names
gamma-tubulin complex component 5	gamma-tubulin complex component GCP5

TUBGCP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TUBGCP5	Q96RT8	HEMK1	Homo sapiens	Q9Y5R4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 25	Cataract, Central Saccular, With Sutural Opacities CTRCT25 Ccsso Cataract, Central Pouch-Like, With Sutural Opacities Central Pouch-Like Cataract With Sutural Opacities Central Saccular Cataract With Sutural Opacities Early-Onset Cataract With Y-Shaped Suture Opacities
Spastic Paraplegia 6, Autosomal Dominant	SPG6 Fsp3 Hereditary Spastic Paraplegia 6 Autosomal Dominant Spastic Paraplegia Type 6 Spastic Paraplegia 6 Familial Spastic Paraplegia Autosomal Dominant 3 Familial Spastic Paraplegia, Autosomal Dominant, 3 Autosomal Dominant Familial Spastic Paraplegia Type 3 Autosomal Dominant Spastic Paraplegia 6 Spastic Paraplegia-6 Paraplegia, Spastic, Type 6
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Chromosome 15q11.2 Deletion Syndrome	15q11.2 Microdeletion Syndrome 15q11.2 Bp1-Bp2 Microdeletion Syndrome Del(15)(Q11.2) Monosomy 15q11.2 15q11.2 Microdeletion Chromosome 15q11.2 Deletion Chromosome 15q11.2 Microdeletion Chromosome Deletion Syndrome 15q11.2 Microdeletion 15q11.2 Duplication 15q11-Q13 Syndrome
Dyscalculia	Disorder Of Arithmetical Skills Mathematics Disorder Developmental Arithmetic Disorder
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations	MCCCHCM
Precocious Puberty, Central, 2	CPPB2 Central Precocious Puberty 2 Precocious Puberty, Central 2 Precocious Puberty, Central, Type 2
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Dyslexia
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15265	TUBGCP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TUBGCP5	VGNC	VGNC:79155
Bos taurus	TUBGCP5	VGNC	VGNC:36515
Rattus norvegicus	TUBGCP5	RGD	RGD:1304689
Mus musculus	TUBGCP5	MGD	MGI:2178836
Canis familiaris	TUBGCP5	VGNC	VGNC:47995
Felis catus	TUBGCP5	VGNC	VGNC:66707
Others	TUBGCP5	NCBI