2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 1

IFN-alpha 1

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IFN-alpha 1 (IFNA1; IFN-α1), belongs to the alpha/beta interferon family, is produced by macrophages with antiviral activities[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2].
IFNs binds to one of three type-specific receptors, which leads to the activation of JAK1 and TYK2[3]. This signal transduction results in phosphorylation of STAT1 and STAT2 and eventually in an association with IFN regulatory factor 9 (IRF9) and formation of the IFN-stimulated gene factor 3 (ISGF3) complex. Thus the ISGF3 complex induces transcription of IFN-stimulated genes (ISGs), with subsequent immunomodulatory effects on both innate and adaptive immune responses[4]. The interactions of type I IFN with the immune system is important for the generation of a durable antitumor response through its effects on dendritic cells (DC)[5].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P700183AF
    Animal-Free IFN alpha 1a Protein, Mouse (His)

    Leukocyte Interferon; IFNA2; B cell Interferon; Type I Interferon

    		Mouse E. coli
  • HY-P70241
    IFN-alpha 1/IFNA1 Protein, Human (HEK293, His)

    rHuInterferon alpha-1, His; Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNA1; IFNA13

    		Human HEK293
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
  • HY-P74866
    IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His)

    IFNA1; IFNalpha 1; IFN-alpha 1

    		Mouse P. pastoris
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.
  • HY-P73245
    IFN-alpha 1/IFNA1 Protein, Human (P.pastoris, His)

    Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13

    		Human P. pastoris
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Human (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.
  • HY-P701053
    IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc)

    Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNalpha 1; IFN alpha1; IFNA1; IFN-alpha-1; Interferon alpha 1

    		Mouse HEK293
Cat. No. Product Name Effect Purity