1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-alpha
  5. IFN-alpha 1

IFN-alpha 1 (IFNA1; IFN-α1), belongs to the alpha/beta interferon family, is produced by macrophages with antiviral activities[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2].
IFNs binds to one of three type-specific receptors, which leads to the activation of JAK1 and TYK2[3]. This signal transduction results in phosphorylation of STAT1 and STAT2 and eventually in an association with IFN regulatory factor 9 (IRF9) and formation of the IFN-stimulated gene factor 3 (ISGF3) complex. Thus the ISGF3 complex induces transcription of IFN-stimulated genes (ISGs), with subsequent immunomodulatory effects on both innate and adaptive immune responses[4]. The interactions of type I IFN with the immune system is important for the generation of a durable antitumor response through its effects on dendritic cells (DC)[5].

Cat. No. Product Name / Synonyms Species Source
  • HY-P700183AF
    Animal-Free IFN alpha 1a Protein, Mouse (His)

    Leukocyte Interferon; IFNA2; B cell Interferon; Type I Interferon

    Mouse E. coli
    IFN alpha 1a Protein, synthesized by macrophages, exhibits robust antiviral activities by stimulating key enzymes—a protein kinase and an oligoadenylate synthetase. This orchestrated molecular response enhances the host's immune defenses against viral threats. Animal-Free IFN alpha 1a Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIFN alpha 1a protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free IFN alpha 1a Protein, Mouse (His) is 166 a.a., with molecular weight of ~19.93 kDa.
  • HY-P70241
    IFN-alpha 1/IFNA1 Protein, Human (HEK293, His)

    rHuInterferon alpha-1, His; Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNA1; IFNA13

    Human HEK293
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.
  • HY-P74864
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, His)

    Interferon alpha-1; IFN-alpha-1; IFNA1

    Rat HEK293
  • HY-P74866
    IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His)

    IFNA1; IFNalpha 1; IFN-alpha 1

    Mouse P. pastoris
    IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1/IFNA1 Protein, Mouse (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.
  • HY-P73245
    IFN-alpha 13/IFNA1 Protein, Human (P.pastoris, His)

    Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13

    Human P. pastoris
    IFN-alpha 13 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 13/IFNA1 Protein, Human (P.pastoris, His) is produced in P.pastoris yeast cells with a C-Terminal His-tag.
  • HY-P701053
    IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc)

    Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNalpha 1; IFN alpha1; IFNA1; IFN-alpha-1; Interferon alpha 1

    Mouse HEK293
    IFN alpha 1a Protein, synthesized by macrophages, exhibits robust antiviral activities by stimulating key enzymes—a protein kinase and an oligoadenylate synthetase. This orchestrated molecular response enhances the host's immune defenses against viral threats. IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived IFN-alpha 1/IFNA1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of IFN-alpha 1/IFNA1 Protein, Mouse (HEK293, hFc) is 166 a.a., with molecular weight of 50-60 kDa.
  • HY-P74865
    IFN-alpha 1/IFNA1 Protein, Rat (HEK293, hFc)

    Interferon alpha-1; IFN-alpha-1; IFNA1

    Rat HEK293
Cat. No. Product Name Effect Purity