CST4 - cystatin S Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1472

About CST4

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,685,640-23,689,038 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 11 paralogues. Restricted expression toward salivary gland (RPKM 5781.4).

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but Antibacterial and Antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul 2008]

CST4 Products (1)

mRNA Protein Name
NM_001899.3 NP_001890.1 cystatin-S precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
3488317 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste IDA
IDA: Inferred from direct assay
24248522 GOA
involved in negative regulation of proteolysis IDA
IDA: Inferred from direct assay
3488317 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
3488317 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CST4 Protein Structure

Cystatin

Cystatin: Cystatin domain (32 - 127)

  • 0
  • 100
  • 141 a.a.
Protein Preferred Names Protein Names

cystatin-S

  • cystatin 4

CST4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CST4 P01036 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
CST4 P01036 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CST4 Proteins

Cat. No. Product Name Accession Purity
HY-P7866 Cystatin S/CST4 Protein, Human (HEK293, His) P01036 (S21-A141) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Blepharitis
Cerebral Amyloid Angiopathy, Cst3-Related

  • Cerebral Amyloid Angiopathy

  • Hereditary Cerebral Hemorrhage With Amyloidosis

  • Hchwa

  • Hereditary Cystatin C Amyloid Angiopathy

  • Cerebral Amyloid Angiopathy, Familial

  • Amyloidosis, Cerebroarterial, Icelandic Type

  • Amyloidosis Vi

  • Cerebral Hemorrhage, Hereditary, With Amyloidosis

  • Cst3-Related Cerebral Amyloid Angiopathy

  • Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

  • Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

  • Caa, Familial

  • Cerebral Amyloid Angiopathy, Genetic

  • Acys Amyloidosis

  • Cst3-Related Amyloidosis

  • Cystatin Amyloidosis

  • Hchwa, Icelandic Type

  • Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

  • Amyloidosis 6

  • AMYL6

  • Acys

  • Caa

  • Cerebral Amyloid Angiopathy Cst3-Related

  • Cerebroarterial Amyloidosis Icelandic Type

  • Cystatin C Amyloidosis

  • Hccaa

  • Hchwai

  • Hchwa-I

  • Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

  • Cerebral Amyloid Angiopathy Familial

  • Angiopathy, Amyloid, Cerebral, Cst3-Related

  • Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

  • Familial Cerebral Amyloid Angiopathy

  • Cerebral Amyloid Angiopathy, Hereditary
Tick Paralysis
Unverricht-Lundborg Syndrome

  • Unverricht-Lundborg Disease

  • Epm1

  • Myoclonic Epilepsy Of Unverricht And Lundborg

  • Myoclonus Progressive Epilepsy Of Unverricht And Lundborg

  • Unverricht - Lundborg Disease

  • Unverricht'S Disease

  • Epilepsy, Progressive Myoclonic Type 1

  • Epilepsy, Progressive Myoclonus 1

  • Progressive Myoclonus Epilepsy Baltic Myoclonic Epilepsy

  • Baltic Myoclonic Epilepsy

  • Baltic Myoclonus

  • Baltic Myoclonus Epilepsy

  • Lundborg-Unverricht Syndrome

  • Mediterranean Myoclonic Epilepsy

  • Pme

  • Progressive Myoclonic Epilepsy

  • Progressive Myoclonus Epilepsy 1

  • Uld

  • Myoclonic Epilepsies, Progressive
Root Caries

  • Cementum Caries

  • Dental Caries Of Root Surface
Progressive Myoclonus Epilepsy

  • Pme

  • Progressive Myoclonic Epilepsy

  • Myoclonic Epilepsies, Progressive

  • Unverricht-Lundborg Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03265 CST4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown