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CLEC11A - C-type lectin domain containing 11A Gene

Also Known as P47; SCGF; LSLCL; CLECSF3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6320

About CLEC11A

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,723,364-50,725,708 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 36.6), endometrium (RPKM 6.5) and 15 other tissues.

Summary

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

CLEC11A Products (1)

mRNA	Protein	Name
NM_002975.3	NP_002966.1	C-type lectin domain family 11 member A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	11920266	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11920266	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	9442024	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC11A Protein Structure

Lectin_C

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
C-type lectin domain family 11 member A	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3

CLEC11A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLEC11A	Q9Y240	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	CLEC11A	Q9Y240	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	CLEC11A	Q9Y240	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	CLEC11A	Q9Y240	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	CLEC11A	Q9Y240	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	CLEC11A	Q9Y240	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	CLEC11A	Q9Y240	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CLEC11A	Q9Y240	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	CLEC11A	Q9Y240	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CLEC11A	Q9Y240	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CLEC11A	Q9Y240	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Benign Mastocytoma
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Piebald Trait	Piebaldism PBT Partial Albinism Albinoidism, Oculocutaneous, Autosomal Dominant
Esophageal Lipoma	Lipoma Of Esophagus
Solitary Mastocytoma Of The Skin	Cutaneous Solitary Mastocytoma Skin Mastocytoma Solitary Mastocytoma Solitary Mastocytoma Of Skin Mastocytoma, Skin
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02780	CLEC11A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21995	Clec11a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28512	Clec11a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLEC11A	RGD	RGD:3627
Mus musculus	CLEC11A	MGD	MGI:1298219
Macaca mulatta	CLEC11A	VGNC	VGNC:71167
Bos taurus	CLEC11A	VGNC	VGNC:27422
Canis familiaris	CLEC11A	VGNC	VGNC:49644
Others	CLEC11A	NCBI