CIDEC - cell death inducing DFFA like effector c Gene

Also Known as CIDE3; FPLD5; FSP27; CIDE-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 63924

About CIDEC

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,866,710-9,880,253 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in fat (RPKM 484.8), small intestine (RPKM 36.2) and 1 other tissue.

Summary

This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in Apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte Apoptosis. This gene is regulated by Insulin and its expression is positively correlated with Insulin sensitivity. Mutations in this gene may contribute to Insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

CIDEC Products (8)

mRNA	Protein	Name
NM_001199551.2	NP_001186480.1	cell death activator CIDE-3 isoform 2
NM_001199552.2	NP_001186481.1	cell death activator CIDE-3 isoform 3
NM_001199623.2	NP_001186552.1	cell death activator CIDE-3 isoform 1
NM_001321142.2	NP_001308071.1	cell death activator CIDE-3 isoform 3
NM_001321143.2	NP_001308072.1	cell death activator CIDE-3 isoform 4
NM_001321144.2	NP_001308073.1	cell death activator CIDE-3 isoform 4
NM_001378491.1	NP_001365420.1	cell death activator CIDE-3 isoform 3
NM_022094.3	NP_071377.2	cell death activator CIDE-3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	12429024	GOA
involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	12429024	GOA
involved in lipid droplet fusion	IDA IDA: Inferred from direct assay	23399566	GOA
involved in lipid droplet organization	IMP IMP: Inferred from mutant phenotype	20049731	GOA
involved in lipid storage	IDA IDA: Inferred from direct assay	18334488	GOA
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	18334488	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	12429024	GOA
is active in lipid droplet	IDA IDA: Inferred from direct assay	23399566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIDEC Protein Structure

CIDE-N

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
cell death activator CIDE-3	fat specific protein 27

CIDEC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CIDEC	Q96AQ7	METTL15	Homo sapiens	A6NJ78-4	Y2H Prey Pooling	32296183
Intra	CIDEC	Q96AQ7	METTL15	Homo sapiens	A6NJ78-4	Y2H Array	32296183
Intra	CIDEC	Q96AQ7	KLHL20	Homo sapiens	Q9BS75	Y2H Array	32296183
Intra	CIDEC	Q96AQ7	KLHL20	Homo sapiens	Q9BS75	Y2H Prey Pooling	32296183
Intra	CIDEC	Q96AQ7	KLHL20	Homo sapiens	Q9BS75	Validated Y2H	32296183
Intra	CIDEC	Q96AQ7	SPATA12	Homo sapiens	Q7Z6I5	Y2H Prey Pooling	32296183
Intra	CIDEC	Q96AQ7	SPATA12	Homo sapiens	Q7Z6I5	Y2H Array	32296183
Intra	CIDEC	Q96AQ7	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	CIDEC	Q96AQ7	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	CIDEC	Q96AQ7	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	CIDEC	Q96AQ7	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	CIDEC	Q96AQ7	NR0B2	Homo sapiens	Q15466	Y2H Prey Pooling	32296183
Intra	CIDEC	Q96AQ7	NR0B2	Homo sapiens	Q15466	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CIDEC Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81068	FSP27/CIDEC Antibody (YA911)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P81068A	FSP27/CIDEC Antibody	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lipodystrophy, Familial Partial, Type 5	FPLD5 Cidec-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 5 Cidec-Related Fpld Familial Partial Lipodystrophy Associated With Cidec Mutations Lipodystrophy, Familial Partial, Associated With Cidec Mutations Lipodystrophy, Familial Partial, 5
Lipodystrophy, Familial Partial, Type 4	FPLD4 Plin1-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 4 Familial Partial Lipodystrophy Associated With Plin1 Mutations Plin1-Related Fpld Lipodystrophy, Familial Partial, Associated With Plin1 Mutations Lipodystrophy, Familial Partial, 4
Familial Partial Lipodystrophy	Lipodystrophy, Familial Partial Fpld Kobberling-Dunnigan Syndrome Dunnigan Syndrome Koberling-Dunnigan Syndrome Dunnigan-Kobberling Syndrome Fpl Familial Partial Lipodystrophy, Type 2
Lipodystrophy, Familial Partial, Type 1	FPLD1 Familial Partial Lipodystrophy Type 1 Familial Partial Lipodystrophy, Kobberling Type Lipodystrophy, Familial Partial, Kobberling Type Familial Partial Lipodystrophy Kobberling Type Familial Partial Lipodystrophy Type Köbberling Familial Partial Lipodystrophy, Köbberling Type Familial Partial Lipodystrophy, Type 1
Lipodystrophy, Familial Partial, Type 2	FPLD2 Lipoatrophic Diabetes Familial Partial Lipodystrophy Type 2 Familial Partial Lipodystrophy, Dunnigan Type Fpl2 Lipoatrophic Diabetes Mellitus Lipodystrophy, Familial Partial, Dunnigan Type Lipodystrophy, Familial, Of Limbs And Lower Trunk Lipodystrophy, Reverse Partial Familial Partial Lipodystrophy Dunnigan Type Dunnigan Syndrome Familial Lipodystrophy Of Limbs And Lower Trunk Reverse Partial Lipodystrophy Lipodystrophy, Familial Partial, 2 Generalized Lipoatrophy Associated With Diabetes, Hepatic Steatosis, Hypertrophic Cardiomyopathy And Leukomelanodermic Papules Lipodystrophy Familial Of Limbs And Lower Trunk Lipodystrophy Reverse Partial Diabetes Mellitus, Lipoatrophic Familial Partial Lipodystrophy, Type 2 Familial Generalized Lipodystrophy
Lipodystrophy, Familial Partial, Type 3	FPLD3 Pparg-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 3 Familial Partial Lipodystrophy Associated With Pparg Mutations Pparg-Related Fpld Lipodystrophy, Familial Partial, Associated With Pparg Mutations Insulin Resistance, Severe, Digenic Lipodystrophy, Familial Partial, 3 Familial Partial Lipodystrophy, Type 3
Lipodystrophy, Familial Partial, Type 6	FPLD6 Lipe-Related Familial Partial Lipodystrophy Familial Partial Lipodystrophy Type 6 Lipe-Related Fpld Lipodystrophy, Familial Partial, Associated With Lipe Mutations Familial Partial Lipodystrophy Associated With Lipe Mutations Lipodystrophy, Familial Partial, 6
Acquired Generalized Lipodystrophy	Lawrence Syndrome Acquired Lipoatrophic Diabetes Lawrence-Seip Syndrome Familial Generalized Lipodystrophy
Complete Generalized Lipodystrophy
Adiposis Dolorosa	Dercum Disease Dercum'S Disease Lipomatosis Dolorosa Adiposalgia Adipose Tissue Rheumatism Anders Syndrome Dercum-Vitaut Syndrome Morbus Dercum
Nodular Nonsuppurative Panniculitis	Weber-Christian Disease Relapsing Febrile Nodular Nonsuppurative Panniculitis Idiopathic Nodular Panniculitis Pfeiffer-Weber-Christian Syndrome Weber-Christian Panniculitis Panniculitis, Nodular Nonsuppurative Nodular Non-Suppurative Febrile Panniculitis Weber - Christian Disease Panniculitis Nodular Nonsuppurative Nodular Non-Suppurative Panniculitis Idiopathic Lobular Panniculitis Relapsing Febrile Nodular Panniculitis Wcd
Lipodystrophy, Congenital Generalized, Type 2	Congenital Generalized Lipodystrophy Type 2 CGL2 Berardinelli-Seip Congenital Lipodystrophy Type 2 Berardinelli-Seip Syndrome Brunzell Syndrome Bscl2-Related Total Lipodystrophy And Acromegaloid Gigantism Berardinelli-Seip Congenital Lipodystrophy, Type 2 Seip Syndrome Berardinelli Syndrome Lipodystrophy, Total, And Acromegaloid Gigantism Lipoatrophic Diabetes, Congenital Lipodystrophy, Berardinelli-Seip Congenital, Type 2 Brunzell Syndrome, Bscl2-Related Congenital Lipoatrophic Diabetes Congenital Generalized Lipodystrophy 2 Lipoatrophic Diabetes Lipodystrophy Berardinelli Type Familial Generalized Lipodystrophy Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS02713	CIDEC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CIDEC	VGNC	VGNC:60902
Mus musculus	CIDEC	MGD	MGI:95585
Rattus norvegicus	CIDEC	RGD	RGD:1562113
Canis familiaris	CIDEC	VGNC	VGNC:39272
Bos taurus	CIDEC	VGNC	VGNC:27365
Macaca mulatta	CIDEC	VGNC	VGNC:71332
Others	CIDEC	NCBI