CIDEC - cell death inducing DFFA like effector c Gene

Homo sapiens

Also known as CIDE3; FPLD5; FSP27; CIDE-3

Gene ID: 63924 | Gene type: protein coding

About CIDEC

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,866,710-9,880,253 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in fat (RPKM 484.8), small intestine (RPKM 36.2) and 1 other tissue.

Summary

This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in Apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte Apoptosis. This gene is regulated by Insulin and its expression is positively correlated with Insulin sensitivity. Mutations in this gene may contribute to Insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

CIDEC Products(8)

mRNA	Protein	Name
NM_001199551.2	NP_001186480.1	cell death activator CIDE-3 isoform 2
NM_001199552.2	NP_001186481.1	cell death activator CIDE-3 isoform 3
NM_001199623.2	NP_001186552.1	cell death activator CIDE-3 isoform 1
NM_001321142.2	NP_001308071.1	cell death activator CIDE-3 isoform 3
NM_001321143.2	NP_001308072.1	cell death activator CIDE-3 isoform 4
NM_001321144.2	NP_001308073.1	cell death activator CIDE-3 isoform 4
NM_001378491.1	NP_001365420.1	cell death activator CIDE-3 isoform 3
NM_022094.3	NP_071377.2	cell death activator CIDE-3 isoform 3

CIDEC Protein Structure

CIDE-N

0
100
200
238 a.a.

Protein Preferred Names

Protein Names

cell death activator CIDE-3

fat specific protein 27

Related Diseases

Diseases

Alias

Lipodystrophy, Familial Partial, Type 5

FPLD5	Cidec-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 5	Cidec-Related Fpld
Familial Partial Lipodystrophy Associated With Cidec Mutations	Lipodystrophy, Familial Partial, Associated With Cidec Mutations
Lipodystrophy, Familial Partial, 5

Lipodystrophy, Familial Partial, Type 4

FPLD4	Plin1-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 4	Familial Partial Lipodystrophy Associated With Plin1 Mutations
Plin1-Related Fpld	Lipodystrophy, Familial Partial, Associated With Plin1 Mutations
Lipodystrophy, Familial Partial, 4

Familial Partial Lipodystrophy

Lipodystrophy, Familial Partial	Fpld
Kobberling-Dunnigan Syndrome	Dunnigan Syndrome
Koberling-Dunnigan Syndrome	Dunnigan-Kobberling Syndrome
Fpl	Familial Partial Lipodystrophy, Type 2

Lipodystrophy, Familial Partial, Type 1

FPLD1	Familial Partial Lipodystrophy Type 1
Familial Partial Lipodystrophy, Kobberling Type	Lipodystrophy, Familial Partial, Kobberling Type
Familial Partial Lipodystrophy Kobberling Type	Familial Partial Lipodystrophy Type Köbberling
Familial Partial Lipodystrophy, Köbberling Type	Familial Partial Lipodystrophy, Type 1

Lipodystrophy, Familial Partial, Type 2

FPLD2	Lipoatrophic Diabetes
Familial Partial Lipodystrophy Type 2	Familial Partial Lipodystrophy, Dunnigan Type
Fpl2	Lipoatrophic Diabetes Mellitus
Lipodystrophy, Familial Partial, Dunnigan Type	Lipodystrophy, Familial, Of Limbs And Lower Trunk
Lipodystrophy, Reverse Partial	Familial Partial Lipodystrophy Dunnigan Type
Dunnigan Syndrome	Familial Lipodystrophy Of Limbs And Lower Trunk
Reverse Partial Lipodystrophy	Lipodystrophy, Familial Partial, 2
Generalized Lipoatrophy Associated With Diabetes, Hepatic Steatosis, Hypertrophic Cardiomyopathy And Leukomelanodermic Papules	Lipodystrophy Familial Of Limbs And Lower Trunk
Lipodystrophy Reverse Partial	Diabetes Mellitus, Lipoatrophic
Familial Partial Lipodystrophy, Type 2	Familial Generalized Lipodystrophy

Lipodystrophy, Familial Partial, Type 3

FPLD3	Pparg-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 3	Familial Partial Lipodystrophy Associated With Pparg Mutations
Pparg-Related Fpld	Lipodystrophy, Familial Partial, Associated With Pparg Mutations
Insulin Resistance, Severe, Digenic	Lipodystrophy, Familial Partial, 3
Familial Partial Lipodystrophy, Type 3

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Acquired Generalized Lipodystrophy

Lawrence Syndrome	Acquired Lipoatrophic Diabetes
Lawrence-Seip Syndrome	Familial Generalized Lipodystrophy

Complete Generalized Lipodystrophy

Adiposis Dolorosa

Dercum Disease	Dercum'S Disease
Lipomatosis Dolorosa	Adiposalgia
Adipose Tissue Rheumatism	Anders Syndrome
Dercum-Vitaut Syndrome	Morbus Dercum

Nodular Nonsuppurative Panniculitis

Weber-Christian Disease	Relapsing Febrile Nodular Nonsuppurative Panniculitis
Idiopathic Nodular Panniculitis	Pfeiffer-Weber-Christian Syndrome
Weber-Christian Panniculitis	Panniculitis, Nodular Nonsuppurative
Nodular Non-Suppurative Febrile Panniculitis	Weber - Christian Disease
Panniculitis Nodular Nonsuppurative	Nodular Non-Suppurative Panniculitis
Idiopathic Lobular Panniculitis	Relapsing Febrile Nodular Panniculitis
Wcd

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02713	CIDEC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CIDEC	VGNC	VGNC:60902
Mus musculus	CIDEC	MGD	MGI:95585
Rattus norvegicus	CIDEC	RGD	RGD:1562113
Canis familiaris	CIDEC	VGNC	VGNC:39272
Bos taurus	CIDEC	VGNC	VGNC:27365
Macaca mulatta	CIDEC	VGNC	VGNC:71332

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