NEDD9 - neural precursor cell expressed, developmentally down-regulated 9 Gene

Also Known as CAS2; CASL; HEF1; CAS-L; CASS2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4739

About NEDD9

Cytogenetic location: 6p24.2 Genomic coordinates (GRCh38): 6:11,183,298-11,382,348 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in lung (RPKM 35.3), placenta (RPKM 25.4) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as Apoptosis and the cell cycle. This protein has also been reported to have a role in Cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

NEDD9 Products (4)

mRNA Protein Name
NM_001142393.2 NP_001135865.1 enhancer of filamentation 1 isoform 3
NM_001271033.2 NP_001257962.1 enhancer of filamentation 1 isoform 4
NM_006403.4 NP_006394.1 enhancer of filamentation 1 isoform 1
NM_182966.4 NP_892011.2 enhancer of filamentation 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9360983 GOA
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
18256281 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium disassembly IMP
IMP: Inferred from mutant phenotype
17604723 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18256281 GOA
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
18256281 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
18256281 GOA
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
17604723 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
19103205 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
16394104 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29899023 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEDD9 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (10 - 60)

Serine_rich

Serine_rich: Serine rich protein interaction domain (404 - 559)

DUF3513

DUF3513: Domain of unknown function (DUF3513) (617 - 828)

  • 0
  • 200
  • 400
  • 600
  • 834 a.a.
Protein Preferred Names Protein Names

enhancer of filamentation 1

  • Cas scaffolding protein family member 2

NEDD9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEDD9 Q14511 PRR20C Homo sapiens P86479
Y2H Prey Pooling
25416956
Intra
NEDD9 Q14511 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
NEDD9 Q14511 NFKBIA Homo sapiens P25963
Y2H Prey Pooling
25416956
Intra
NEDD9 Q14511 NFKBIA Homo sapiens P25963
Y2H Array
25416956
Intra
NEDD9 Q14511 BCAR3 Homo sapiens O75815
Y2H Prey Pooling
25416956
Intra
NEDD9 Q14511 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
NEDD9 Q14511 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
NEDD9 Q14511 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra
NEDD9 Q14511 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
NEDD9 Q14511 RFX6 Homo sapiens Q8HWS3
Validated Y2H
25416956
Intra
NEDD9 Q14511 RFX6 Homo sapiens Q8HWS3
Y2H Array
25416956
Intra
NEDD9 Q14511 NAB2 Homo sapiens Q15742
Y2H Array
25416956
Intra
NEDD9 Q14511 NAB2 Homo sapiens Q15742
Y2H
21516116
Cross: Cross-species interaction Intra: Intraspecies interaction

NEDD9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84571 NEDD9 Antibody (YA4268) WB, ICC/IF, FC, ELISA Human, Rat
HY-P84571A NEDD9 Antibody (YA4268)(PBS only) WB, ICC/IF, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Palmoplantar Keratoderma And Congenital Alopecia 2

  • Cataract-Alopecia-Sclerodactyly Syndrome

  • Cass

  • Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia

  • PPKCA2

  • Autosomal Recessive Palmoplantar Hyperkeratosis And Congenital Alopecia

  • Palmoplantar Keratoderma And Congenital Alopecia, Wallis Type

  • Ppk-Ca, Wallis Type

  • Cataract, Alopecia, Sclerodactyly

  • Ppkca, Wallis Type

  • Ppkca Wallis Type

  • Cataract, Alopecia, Sclerodactyly Syndrome
Meckel Syndrome, Type 1

  • Meckel-Gruber Syndrome

  • Meckel Syndrome

  • Dysencephalia Splanchnocystica

  • Meckel Syndrome 1

  • MKS1

  • Mks

  • Gruber Syndrome

  • Meckel-Gruber Syndrome, Type 1

  • Mes

  • Dysencephalia Splachnocystica

  • Meckel Gruber Syndrome

  • Meckel Syndrome Type 1
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183628 MEAP Modulator / Unkown
HY-RS09182 NEDD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21663 Nedd9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28181 Nedd9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NEDD9 VGNC VGNC:75304
Bos taurus NEDD9 VGNC VGNC:31984
Felis catus NEDD9 VGNC VGNC:68453
Mus musculus NEDD9 MGD MGI:97302
Canis familiaris NEDD9 VGNC VGNC:43722
Rattus norvegicus NEDD9 RGD RGD:1306276
Others NEDD9 NCBI