BCAR3 - BCAR3 adaptor protein, NSP family member Gene

Also Known as MIG7; NSP2; AND-34; SH2D3B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8412

About BCAR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,561,741-93,847,219 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues.

Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast Cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast Cancer cells. The protein contains a putative Src homology 2 (SH2) domain, a hall MARK of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BCAR3 Products (33)

mRNA Protein Name
NM_001261408.2 NP_001248337.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261409.1 NP_001248338.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261410.2 NP_001248339.1 breast cancer anti-estrogen resistance protein 3 isoform 2
NM_001308251.1 NP_001295180.1 breast cancer anti-estrogen resistance protein 3 isoform 3
NM_001412043.1 NP_001398972.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412044.1 NP_001398973.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412045.1 NP_001398974.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412046.1 NP_001398975.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412048.1 NP_001398977.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412049.1 NP_001398978.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412050.1 NP_001398979.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412051.1 NP_001398980.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412052.1 NP_001398981.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412054.1 NP_001398983.1 breast cancer anti-estrogen resistance protein 3 isoform 4
NM_001412055.1 NP_001398984.1 breast cancer anti-estrogen resistance protein 3 isoform 5
NM_001412056.1 NP_001398985.1 breast cancer anti-estrogen resistance protein 3 isoform 6
NM_001412057.1 NP_001398986.1 breast cancer anti-estrogen resistance protein 3 isoform 7
NM_001412058.1 NP_001398987.1 breast cancer anti-estrogen resistance protein 3 isoform 8
NM_001412059.1 NP_001398988.1 breast cancer anti-estrogen resistance protein 3 isoform 9
NM_001412060.1 NP_001398989.1 breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412061.1 NP_001398990.1 breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412062.1 NP_001398991.1 breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412064.1 NP_001398993.1 breast cancer anti-estrogen resistance protein 3 isoform 12
NM_001412065.1 NP_001398994.1 breast cancer anti-estrogen resistance protein 3 isoform 13
NM_001412066.1 NP_001398995.1 breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412067.1 NP_001398996.1 breast cancer anti-estrogen resistance protein 3 isoform 15
NM_001412072.1 NP_001399001.1 breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412073.1 NP_001399002.1 breast cancer anti-estrogen resistance protein 3 isoform 16
NM_001412074.1 NP_001399003.1 breast cancer anti-estrogen resistance protein 3 isoform 17
NM_001412075.1 NP_001399004.1 breast cancer anti-estrogen resistance protein 3 isoform 18
NM_001412076.1 NP_001399005.1 breast cancer anti-estrogen resistance protein 3 isoform 19
NM_001412077.1 NP_001399006.1 breast cancer anti-estrogen resistance protein 3 isoform 8
NM_003567.4 NP_003558.1 breast cancer anti-estrogen resistance protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
18722344 GOA
enables phosphotyrosine residue binding IMP
IMP: Inferred from mutant phenotype
24216110 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Biological Process GO Annotation Evidence References Source
involved in endothelin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19086031 GOA
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18722344 GOA
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24216110 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
19086031 GOA
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
24216110 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18722344 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAR3 Protein Structure

SH2

SH2: SH2 domain (154 - 234)

RasGEF

RasGEF: RasGEF domain (597 - 696)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
Protein Preferred Names Protein Names

breast cancer anti-estrogen resistance protein 3

  • BCAR3, NSP family adaptor protein

BCAR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCAR3 O75815 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra
BCAR3 O75815 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra
BCAR3 O75815 KIT Homo sapiens P10721
FPS
24728074
Intra
BCAR3 O75815 NEDD9 Homo sapiens Q14511
Anti Tag CoIP
33961781
Intra
BCAR3 O75815 NEDD9 Homo sapiens Q14511
Validated Y2H
25416956
Intra
BCAR3 O75815 NEDD9 Homo sapiens Q14511
Anti Tag CoIP
28514442
Intra
BCAR3 O75815 NEDD9 Homo sapiens Q14511
Y2H Array
25416956
Intra
BCAR3 O75815 FUS Homo sapiens P35637
Validated Y2H
32814053
Intra
BCAR3 O75815 FUS Homo sapiens P35637
Y2H Pooling
32814053
Intra
BCAR3 O75815 FUS Homo sapiens P35637
Anti Bait CoIP
17353931
Intra
BCAR3 O75815 FUS Homo sapiens P35637
Y2H Array
32814053
Intra
BCAR3 O75815 IRS1 Homo sapiens P35568
Y2H Array
25814554
Intra
BCAR3 O75815 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra
BCAR3 O75815 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
BCAR3 O75815 UBASH3A Homo sapiens P57075-2
Validated Y2H
32296183
Intra
BCAR3 O75815 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
32296183
Intra
BCAR3 O75815 OSGIN1 Homo sapiens Q9UJX0
Y2H Array
25640309
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Estrogen Resistance

  • Estrogen Resistance Syndrome

  • ESTRR

  • Estrogen Insensitivity
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01398 BCAR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCAR3 VGNC VGNC:70235
Mus musculus BCAR3 MGD MGI:1352501
Felis catus BCAR3 VGNC VGNC:69195
Canis familiaris BCAR3 VGNC VGNC:49077
Rattus norvegicus BCAR3 RGD RGD:1311688
Bos taurus BCAR3 VGNC VGNC:53850
Others BCAR3 NCBI