SHISA6 - shisa family member 6 Gene

Homo sapiens

Gene ID: 388336 | Gene type: protein coding

About SHISA6

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:11,241,213-11,564,063 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.7), endometrium (RPKM 2.0) and 9 other tissues.

Summary

Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; regulation of short-term neuronal synaptic plasticity; and regulation of signal transduction. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHISA6 Products(3)

mRNA	Protein	Name
NM_001173461.1	NP_001166932.1	protein shisa-6 isoform 2 precursor
NM_001173462.2	NP_001166933.1	protein shisa-6 isoform 3 precursor
NM_207386.4	NP_997269.2	protein shisa-6 isoform 1 precursor

SHISA6 Protein Structure

Shisa

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

protein shisa-6

protein shisa-6 homolog

Related Diseases

Diseases

Alias

Scleral Staphyloma

Scleral Ectasia

Staphyloma Of Sclera

Degenerative Myopia

Pathological Myopia	Myopia, Degenerative
Degenerative Progressive High Myopia	Progressive High Myopia
Progressive High Myopia

Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3	GS3
Griscelli-Prunieras Syndrome Type 3	Hypomelanosis With No Immunologic Or Neurologic Manifestations
Griscelli Syndrome 3

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

Christ-Siemens-Touraine Syndrome	XHED
Ectodermal Dysplasia 1	Xlhed
Ed1	Cst Syndrome
Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked	Ectd1
Ectodermal Dysplasia, Anhidrotic, X-Linked	Eda
Eda1	Hed1
Ectodermal Dysplasia 1, Anhidrotic	X-Linked Anhidrotic Ectodermal Dysplasia
X-Linked Hypohidrotic Ectodermal Dysplasia	Hypohidrotic X-Linked Ectodermal Dysplasia
Ectodermal Dysplasia, Hypohidrotic, 1	Hypohidrotic Ectodermal Dysplasia, X-Linked
Anhidrotic Ectodermal Dysplasia X-Linked	Hypohidrotic Ectodermal Dysplasia X-Linked
Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked	Ectodermal Dysplasia Anhidrotic

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12869	SHISA6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SHISA6	VGNC	VGNC:99449
Macaca mulatta	SHISA6	VGNC	VGNC:104650
Rattus norvegicus	SHISA6	RGD	RGD:1564618
Canis familiaris	SHISA6	VGNC	VGNC:46148
Mus musculus	SHISA6	MGD	MGI:2685725

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