SHISA6 - shisa family member 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 388336

About SHISA6

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:11,241,213-11,564,063 (from NCBI)

This gene has 4 transcripts (splice variants), 281 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.7), endometrium (RPKM 2.0) and 9 other tissues.

Summary

Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including excitatory chemical synaptic transmission; regulation of short-term neuronal synaptic plasticity; and regulation of signal transduction. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHISA6 Products (3)

mRNA Protein Name
NM_001173461.1 NP_001166932.1 protein shisa-6 isoform 2 precursor
NM_001173462.2 NP_001166933.1 protein shisa-6 isoform 3 precursor
NM_207386.4 NP_997269.2 protein shisa-6 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHISA6 Protein Structure

Shisa

Shisa: Wnt and FGF inhibitory regulator (90 - 271)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
Protein Preferred Names Protein Names

protein shisa-6

  • protein shisa-6 homolog

SHISA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHISA6 Q6ZSJ9 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 NEDD4 Homo sapiens P46934-3
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 NEDD4 Homo sapiens P46934-3
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 FBLIM1 Homo sapiens Q8WUP2
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 FBLIM1 Homo sapiens Q8WUP2
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 FBLIM1 Homo sapiens Q8WUP2
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
SHISA6 Q6ZSJ9 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
SHISA6 Q6ZSJ9 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
SHISA6 Q6ZSJ9 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Scleral Staphyloma

  • Scleral Ectasia

  • Staphyloma Of Sclera
Degenerative Myopia

  • Pathological Myopia

  • Myopia, Degenerative

  • Degenerative Progressive High Myopia

  • Progressive High Myopia

  • Progressive High Myopia
Griscelli Syndrome, Type 3

  • Griscelli Syndrome Type 3

  • GS3

  • Griscelli-Prunieras Syndrome Type 3

  • Hypomelanosis With No Immunologic Or Neurologic Manifestations

  • Griscelli Syndrome 3
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

  • Christ-Siemens-Touraine Syndrome

  • XHED

  • Ectodermal Dysplasia 1

  • Xlhed

  • Ed1

  • Cst Syndrome

  • Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked

  • Ectd1

  • Ectodermal Dysplasia, Anhidrotic, X-Linked

  • Eda

  • Eda1

  • Hed1

  • Ectodermal Dysplasia 1, Anhidrotic

  • X-Linked Anhidrotic Ectodermal Dysplasia

  • X-Linked Hypohidrotic Ectodermal Dysplasia

  • Hypohidrotic X-Linked Ectodermal Dysplasia

  • Ectodermal Dysplasia, Hypohidrotic, 1

  • Hypohidrotic Ectodermal Dysplasia, X-Linked

  • Anhidrotic Ectodermal Dysplasia X-Linked

  • Hypohidrotic Ectodermal Dysplasia X-Linked

  • Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked

  • Ectodermal Dysplasia Anhidrotic
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12869 SHISA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SHISA6 VGNC VGNC:99449
Macaca mulatta SHISA6 VGNC VGNC:104650
Rattus norvegicus SHISA6 RGD RGD:1564618
Canis familiaris SHISA6 VGNC VGNC:46148
Mus musculus SHISA6 MGD MGI:2685725
Others SHISA6 NCBI