TRIP6 Antibody (YA4290)(PBS only)
(Synonyms: OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2)TRIP6 Antibody (YA4290) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIP6.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, FC, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
FC
FC: Flow Cytometry
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
TRIP6 Antibody (YA4290) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIP6.
-
Host Mouse
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 50 kDa
Purified recombinant fragment of human TRIP6 (AA: 107-291) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
TRIP6 is a Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor
-
Subcellular Localization
Cytoplasm, cytoskeleton; Cell junction, focal adhesion; Nucleus; Cytoplasm
-
Expression
Tissue_specificity:Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors -
Isoforms & Post-Translational Modification
Q15654 has 3 isomers: Q15654-1: 50288 Da (predicted); Q15654-2: 10602 Da (predicted); Q15654-3: 8277 Da (predicted).
Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13 -
Subunit
Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (PubMed:14688263). Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain) (PubMed:10400701, PubMed:10826496, PubMed:17591779, PubMed:19017743). Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain) (PubMed:10826496). Found in a complex with PTPN13 and PDLIM4 (By similarity). Interacts with SVIL isoform 2 (PubMed:16880273). Interacts with LPAR2 but not other LPA receptors (PubMed:14688263). Interacts with PRKAA2 (PubMed:16624523). Interacts with MAGI1 (PubMed:19017743). Interacts with SCRIB (PubMed:16137684). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609)
-
SwissProt ID
-
Synonyms
OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
Documentation
Powered by Bioz
