MSRB3 - methionine sulfoxide reductase B3 Gene

Homo sapiens

Also known as DFNB74

Gene ID: 253827 | Gene type: protein coding

About MSRB3

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:65,278,683-65,466,907 (from NCBI)

This gene has 17 transcripts (splice variants), 209 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in endometrium (RPKM 66.2), esophagus (RPKM 57.7) and 22 other tissues.

Summary

The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This Enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]

MSRB3 Products(4)

mRNA	Protein	Name
NM_001031679.3	NP_001026849.1	methionine-R-sulfoxide reductase B3 isoform 2 precursor
NM_001193460.2	NP_001180389.1	methionine-R-sulfoxide reductase B3 isoform 2 precursor
NM_001193461.2	NP_001180390.1	methionine-R-sulfoxide reductase B3 isoform 2 precursor
NM_198080.4	NP_932346.1	methionine-R-sulfoxide reductase B3 isoform 1 precursor

MSRB3 Protein Structure

SelR

0
100
192 a.a.

Protein Preferred Names

Protein Names

methionine-R-sulfoxide reductase B3

methionine-R-sulfoxide reductase B3, mitochondrial

Recombinant MSRB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76500	MSRB3 Protein, Human (HEK293, Fc)	Q8IXL7-2 (G26-D181)	≥95%
HY-P76501	MSRB3 Protein, Human (HEK293, His)	Q8IXL7-2 (G26-D181)	≥95%
HY-P76502	MSRB3 Protein, Human (His)	Q8IXL7-2 (G26-L185)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 74

DFNB74	Autosomal Recessive Nonsyndromic Deafness 74
Autosomal Recessive Deafness 74	Deafness, Autosomal Recessive, 74
Deafness, Autosomal Recessive, Type 74

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Deafness, Autosomal Recessive

Lipoma Of Colon

Colonic Lipoma

Colon Lipoma

Large Intestine Lipoma

Lipoma Of Large Intestine

Colorectal Lipoma

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Deafness, Autosomal Dominant 51

Chromosome 9q21.11 Duplication Syndrome	DFNA51
Autosomal Dominant Nonsyndromic Deafness 51	Autosomal Dominant Deafness 51
Deafness, Autosomal Dominant, Type 51

Deafness, Autosomal Recessive 44

DFNB44	Autosomal Recessive Nonsyndromic Deafness 44
Autosomal Recessive Deafness 44	Deafness, Autosomal Recessive, 44
Deafness, Autosomal Recessive, Type 44

Osteopoikilosis

Osteopathia Condensans Disseminata	Spotted Bones
Dermatofibrosis Lenticularis Disseminata

Invasive Bladder Transitional Cell Carcinoma

Invasive Bladder Urothelial Carcinoma

Infiltrating Bladder Urothelial Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08728	MSRB3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSRB3	VGNC	VGNC:74842
Rattus norvegicus	MSRB3	RGD	RGD:1596851
Mus musculus	MSRB3	MGD	MGI:2443538
Canis familiaris	MSRB3	VGNC	VGNC:43451
Bos taurus	MSRB3	VGNC	VGNC:54457
Others	MSRB3	NCBI

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