MSRB3 - methionine sulfoxide reductase B3 Gene

Also Known as DFNB74

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 253827

About MSRB3

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:65,278,683-65,466,907 (from NCBI)

This gene has 17 transcripts (splice variants), 209 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in endometrium (RPKM 66.2), esophagus (RPKM 57.7) and 22 other tissues.

Summary

The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the Other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]

MSRB3 Products (4)

mRNA	Protein	Name
NM_001031679.3	NP_001026849.1	methionine-R-sulfoxide reductase B3 isoform 2 precursor
NM_001193460.2	NP_001180389.1	methionine-R-sulfoxide reductase B3 isoform 2 precursor
NM_001193461.2	NP_001180390.1	methionine-R-sulfoxide reductase B3 isoform 2 precursor
NM_198080.4	NP_932346.1	methionine-R-sulfoxide reductase B3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptide-methionine (R)-S-oxide reductase activity	IDA IDA: Inferred from direct assay	14699060	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	14699060	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein repair	IDA IDA: Inferred from direct assay	14699060	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14699060	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	14699060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSRB3 Protein Structure

SelR

0
100
192 a.a.

Protein Preferred Names	Protein Names
methionine-R-sulfoxide reductase B3	methionine-R-sulfoxide reductase B3, mitochondrial

MSRB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MSRB3	Q8IXL7	PRDM4	Homo sapiens	Q9UKN5	Y2H Array	25416956
Intra	MSRB3	Q8IXL7	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	MSRB3	Q8IXL7	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	MSRB3	Q8IXL7	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MSRB3	Q8IXL7	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	MSRB3	Q8IXL7	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
Intra	MSRB3	Q8IXL7	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MSRB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76500	MSRB3 Protein, Human (HEK293, Fc)	Q8IXL7-2 (G26-D181)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P76501	MSRB3 Protein, Human (HEK293, His)	Q8IXL7-2 (G26-D181)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76502	MSRB3 Protein, Human (His)	Q8IXL7-2 (G26-L185)	≥ 95%, as determined by reducing SDS-PAGE.

MSRB3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83507	MSRB3 Antibody (YA3252)	WB	Mouse, Rat
HY-P83507A	MSRB3 Antibody (YA3252)(PBS only)	WB	Mouse, Rat

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 74	DFNB74 Autosomal Recessive Nonsyndromic Deafness 74 Autosomal Recessive Deafness 74 Deafness, Autosomal Recessive, 74 Deafness, Autosomal Recessive, Type 74
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Deafness, Autosomal Recessive
Lipoma Of Colon	Colonic Lipoma Colon Lipoma
Large Intestine Lipoma	Lipoma Of Large Intestine Colorectal Lipoma
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic
Deafness, Autosomal Dominant 51	Chromosome 9q21.11 Duplication Syndrome DFNA51 Autosomal Dominant Nonsyndromic Deafness 51 Autosomal Dominant Deafness 51 Deafness, Autosomal Dominant, Type 51
Deafness, Autosomal Recessive 44	DFNB44 Autosomal Recessive Nonsyndromic Deafness 44 Autosomal Recessive Deafness 44 Deafness, Autosomal Recessive, 44 Deafness, Autosomal Recessive, Type 44
Osteopoikilosis	Osteopathia Condensans Disseminata Spotted Bones Dermatofibrosis Lenticularis Disseminata
Invasive Bladder Transitional Cell Carcinoma	Invasive Bladder Urothelial Carcinoma Infiltrating Bladder Urothelial Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08728	MSRB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19718	Msrb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26214	Msrb3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSRB3	VGNC	VGNC:74842
Rattus norvegicus	MSRB3	RGD	RGD:1596851
Mus musculus	MSRB3	MGD	MGI:2443538
Canis familiaris	MSRB3	VGNC	VGNC:43451
Bos taurus	MSRB3	VGNC	VGNC:54457
Others	MSRB3	NCBI