HOXB9 - homeobox B9 Gene

Also Known as HOX2; HOX2E; HOX-2.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3219

About HOXB9

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,621,156-48,626,358 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 42 paralogues. Biased expression in colon (RPKM 12.6), kidney (RPKM 7.0) and 3 other tissues.

Summary

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate Cancer and lung Cancer. [provided by RefSeq, Jul 2008]

HOXB9 Products (1)

mRNA Protein Name
NM_024017.5 NP_076922.1 homeobox protein Hox-B9

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10617598 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in cell chemotaxis IDA
IDA: Inferred from direct assay
19576624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXB9 Protein Structure

Hox9_act

Hox9_act: Hox9 activation region (1 - 172)

Homeobox

Homeobox: Homeobox domain (186 - 242)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B9

  • homeo box 2E

HOXB9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXB9 P17482 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
HOXB9 P17482 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
HOXB9 P17482 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
HOXB9 P17482 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
Intra
HOXB9 P17482 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
HOXB9 P17482 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra
HOXB9 P17482 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25416956
Intra
HOXB9 P17482 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP12-2 Homo sapiens P59991
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
HOXB9 P17482 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
HOXB9 P17482 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP1-5 Homo sapiens Q9BYS1
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
HOXB9 P17482 PCSK5 Homo sapiens Q92824-2
Validated Y2H
32296183
Intra
HOXB9 P17482 PCSK5 Homo sapiens Q92824-2
Y2H Array
32296183
Intra
HOXB9 P17482 PCSK5 Homo sapiens Q92824-2
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
HOXB9 P17482 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra
HOXB9 P17482 TENM4 Homo sapiens Q6N022
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 TENM4 Homo sapiens Q6N022
Validated Y2H
32296183
Intra
HOXB9 P17482 TENM4 Homo sapiens Q6N022
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
HOXB9 P17482 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
HOXB9 P17482 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
Intra
HOXB9 P17482 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
HOXB9 P17482 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
HOXB9 P17482 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
HOXB9 P17482 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
HOXB9 P17482 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra
HOXB9 P17482 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
HOXB9 P17482 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
HOXB9 P17482 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
HOXB9 P17482 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HOXB9 P17482 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
HOXB9 P17482 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
HOXB9 P17482 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
HOXB9 P17482 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
HOXB9 P17482 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
HOXB9 P17482 SAT1 Homo sapiens P21673
Y2H Pooling
16189514
Intra
HOXB9 P17482 SAT1 Homo sapiens P21673
Y2H Prey Pooling
25416956
Intra
HOXB9 P17482 SAT1 Homo sapiens P21673
Y2H Array
19060904
Intra
HOXB9 P17482 SAT1 Homo sapiens P21673
Y2H Pooling
19060904
Intra
HOXB9 P17482 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
HOXB9 P17482 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 MDFI Homo sapiens Q99750
Y2H Array
19060904
Intra
HOXB9 P17482 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
HOXB9 P17482 MDFI Homo sapiens Q99750
Y2H Pooling
19060904
Intra
HOXB9 P17482 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
HOXB9 P17482 MDFI Homo sapiens Q99750
Y2H Pooling
16189514
Intra
HOXB9 P17482 HSPB2 Homo sapiens Q16082
Validated Y2H
32296183
Intra
HOXB9 P17482 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
Intra
HOXB9 P17482 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
HOXB9 P17482 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
HOXB9 P17482 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
HOXB9 P17482 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
HOXB9 P17482 LZTS2 Homo sapiens Q9BRK4
Y2H
21516116
Intra
HOXB9 P17482 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
HOXB9 P17482 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Intra
HOXB9 P17482 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
HOXB9 P17482 SFMBT1 Homo sapiens Q9UHJ3
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 SFMBT1 Homo sapiens Q9UHJ3
Validated Y2H
32296183
Intra
HOXB9 P17482 SFMBT1 Homo sapiens Q9UHJ3
Y2H Array
32296183
Intra
HOXB9 P17482 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
Intra
HOXB9 P17482 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
HOXB9 P17482 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
HOXB9 P17482 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
HOXB9 P17482 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
HOXB9 P17482 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra
HOXB9 P17482 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
Intra
HOXB9 P17482 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
HOXB9 P17482 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra
HOXB9 P17482 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
HOXB9 P17482 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
HOXB9 P17482 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HOXB9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83272 HOXB9 Antibody (YA3017) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06313 HOXB9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20421 Hoxb9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26930 Hoxb9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HOXB9 VGNC VGNC:104622
Felis catus HOXB9 VGNC VGNC:99088
Mus musculus HOXB9 MGD MGI:96190
Canis familiaris HOXB9 VGNC VGNC:41755
Bos taurus HOXB9 VGNC VGNC:29922
Rattus norvegicus HOXB9 RGD RGD:1306158
Others HOXB9 NCBI