PIGS - phosphatidylinositol glycan anchor biosynthesis class S Gene

Also Known as DEE95; PIG-S; GPIBD18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94005

About PIGS

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,553,387-28,571,524 (from NCBI)

This gene has 35 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 16.8), kidney (RPKM 16.1) and 25 other tissues.

Summary

This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]

PIGS Products (1)

mRNA Protein Name
NM_033198.4 NP_149975.1 GPI transamidase component PIG-S

PIGS Protein Structure

PIG-S

PIG-S: Phosphatidylinositol-glycan biosynthesis class S protein (21 - 550)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
Protein Preferred Names Protein Names

GPI transamidase component PIG-S

  • GPI transamidase subunit

PIGS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIGS Q96S52 KRT40 Homo sapiens Q6A162 25416956
Intra
PIGS Q96S52 KRTAP10-9 Homo sapiens P60411 32296183
Intra
PIGS Q96S52 KRTAP10-9 Homo sapiens P60411 32296183
Intra
PIGS Q96S52 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
PIGS Q96S52 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
PIGS Q96S52 KRTAP9-2 Homo sapiens Q9BYQ4 32296183
Intra
PIGS Q96S52 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
PIGS Q96S52 KRTAP1-3 Homo sapiens Q8IUG1 32296183
Intra
PIGS Q96S52 KRTAP19-2 Homo sapiens Q3LHN2 32296183
Intra
PIGS Q96S52 KRTAP19-2 Homo sapiens Q3LHN2 32296183
Intra
PIGS Q96S52 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
PIGS Q96S52 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
PIGS Q96S52 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
PIGS Q96S52 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
PIGS Q96S52 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
PIGS Q96S52 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
PIGS Q96S52 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
PIGS Q96S52 PIGT Homo sapiens Q969N2 12802054
Intra
PIGS Q96S52 PIGT Homo sapiens Q969N2 11483512
Intra
PIGS Q96S52 TRIP6 Homo sapiens Q15654 32296183
Intra
PIGS Q96S52 TRIP6 Homo sapiens Q15654 32296183
Intra
PIGS Q96S52 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 95
  • Glycosylphosphatidylinositol Biosynthesis Defect 18

  • GPIBD18

  • DEE95

Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 4
  • MCAHS4

  • Glycosylphosphatidylinositol Biosynthesis Defect 19

  • Gpibd19

  • Developmental And Epileptic Encephalopathy 77

  • Epileptic Encephalopathy, Early Infantile, 77

  • Dee77

  • Eiee77

  • Developmental And Epileptic Encephalopathy, 77

  • Early Infantile Epileptic Encephalopathy 77

  • Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome-4

Developmental And Epileptic Encephalopathy 55
  • DEE55

  • Glycosylphosphatidylinositol Biosynthesis Defect 14

  • Gpibd14

  • Epileptic Encephalopathy, Early Infantile, 55

  • Eiee55

  • Developmental And Epileptic Encephalopathy, 55

  • Early Infantile Epileptic Encephalopathy 55

  • Encephalopathy, Epileptic, Early Infantile, Type 55

Developmental And Epileptic Encephalopathy 80
  • DEE80

  • Glycosylphosphatidylinositol Biosynthesis Defect 20

  • Gpibd20

  • Epileptic Encephalopathy, Early Infantile, 80

  • Eiee80

  • Developmental And Epileptic Encephalopathy, 80

  • Early Infantile Epileptic Encephalopathy 80

Early Infantile Epileptic Encephalopathy
  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma