PIGS - phosphatidylinositol glycan anchor biosynthesis class S Gene
Also Known as DEE95; PIG-S; GPIBD18
Species: Homo sapiens
About PIGS
This gene has 35 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 16.8), kidney (RPKM 16.1) and 25 other tissues.
Summary
This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
PIGS Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_033198.4 | NP_149975.1 | GPI transamidase component PIG-S |
PIGS Protein Structure
PIG-S: Phosphatidylinositol-glycan biosynthesis class S protein (21 - 550)
- 0
- 100
- 200
- 300
- 400
- 500
- 555 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
GPI transamidase component PIG-S |
|
PIGS Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
PIGS | Q96S52 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
PIGS | Q96S52 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP10-9 | Homo sapiens | P60411 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP9-2 | Homo sapiens | Q9BYQ4 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP1-3 | Homo sapiens | Q8IUG1 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP1-3 | Homo sapiens | Q8IUG1 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP19-2 | Homo sapiens | Q3LHN2 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP19-2 | Homo sapiens | Q3LHN2 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | PIGT | Homo sapiens | Q969N2 | 12802054 | |
|
Intra
|
PIGS | Q96S52 | PIGT | Homo sapiens | Q969N2 | 11483512 | |
|
Intra
|
PIGS | Q96S52 | TRIP6 | Homo sapiens | Q15654 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | TRIP6 | Homo sapiens | Q15654 | 32296183 | |
|
Intra
|
PIGS | Q96S52 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Developmental And Epileptic Encephalopathy 95 |
|
|
| Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 4 |
|
|
| Developmental And Epileptic Encephalopathy 55 |
|
|
| Developmental And Epileptic Encephalopathy 80 |
|
|
| Early Infantile Epileptic Encephalopathy |
|
|