2. Gene
  3. PIGS - phosphatidylinositol glycan anchor biosynthesis class S Gene

PIGS - phosphatidylinositol glycan anchor biosynthesis class S Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as DEE95; PIG-S; GPIBD18

Gene ID: 94005 | Gene type: protein coding

About PIGS

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,553,387-28,571,524 (from NCBI)

This gene has 35 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 16.8), kidney (RPKM 16.1) and 25 other tissues.

Summary

This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit Enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]

PIGS Products(1)

mRNA Protein Name
NM_033198.4 NP_149975.1 GPI transamidase component PIG-S

PIGS Protein Structure

PIG-S

PIG-S: Phosphatidylinositol-glycan biosynthesis class S protein (21 - 550)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
Protein Preferred Names Protein Names

GPI transamidase component PIG-S

GPI transamidase subunit

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 95

Glycosylphosphatidylinositol Biosynthesis Defect 18

GPIBD18

DEE95
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 4

MCAHS4

Glycosylphosphatidylinositol Biosynthesis Defect 19

Gpibd19

Developmental And Epileptic Encephalopathy 77

Epileptic Encephalopathy, Early Infantile, 77

Dee77

Eiee77

Developmental And Epileptic Encephalopathy, 77

Early Infantile Epileptic Encephalopathy 77

Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome-4
Developmental And Epileptic Encephalopathy 55

DEE55

Glycosylphosphatidylinositol Biosynthesis Defect 14

Gpibd14

Epileptic Encephalopathy, Early Infantile, 55

Eiee55

Developmental And Epileptic Encephalopathy, 55

Early Infantile Epileptic Encephalopathy 55

Encephalopathy, Epileptic, Early Infantile, Type 55
Developmental And Epileptic Encephalopathy 80

DEE80

Glycosylphosphatidylinositol Biosynthesis Defect 20

Gpibd20

Epileptic Encephalopathy, Early Infantile, 80

Eiee80

Developmental And Epileptic Encephalopathy, 80

Early Infantile Epileptic Encephalopathy 80
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17498 Atenolol Antagonist 99.94% Yes
HY-121383 Labetalol Antagonist 99.88% Unkown
HY-17403 Manidipine dihydrochloride Inhibitor 99.91% Unkown
HY-B0273 Sulfadiazine Inhibitor 99.93% Yes
HY-70050C Alosetron Hydrochloride Antagonist 99.76% Unkown
HY-134004 Pentoxyverine 98.91% Unkown
HY-B1055 Pentoxyverine citrate 99.63% Unkown
HY-P0004 Lysipressin Activator 98.02% Unkown
HY-P0004A Lysipressin acetate Activator 99.43% Unkown
HY-B1404 Nylidrin hydrochloride 99.89% Unkown
HY-101810 Tazanolast 99.50% Unkown
HY-70050A Alosetron Antagonist / Unkown
HY-121166 Levobetaxolol Antagonist / Unkown
HY-17498R Atenolol (Standard) Antagonist / Unkown
HY-70050CR Alosetron Hydrochloride (Standard) Antagonist / Unkown
HY-70050 Alosetron (Hydrochloride(1:X)) Antagonist / Unkown
HY-70050B Alosetron ((Z)-2-butenedioate) Antagonist / Unkown
Clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-13402 Varespladib Inhibitor 99.94% Phase 3
HY-18600A Azimilide dihydrochloride Inhibitor 98.91% Phase 3
HY-107384 Asimadoline Agonist 99.36% Phase 3
HY-18600 Azimilide Inhibitor / Phase 3
HY-13510 Cutamesine dihydrochloride Agonist 98.01% Phase 2
HY-18099A S1RA hydrochloride Antagonist 99.85% Phase 2
HY-18099 S1RA Antagonist 99.43% Phase 2
HY-115831 SAR247799 Agonist 97.21% Phase 1
HY-13438 AZD3839 free base Inhibitor 99.98% Phase 1
HY-115877 GDC-0334 Antagonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (176)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50202 Etomoxir Inducer 99.92% Yes
HY-50202A Etomoxir sodium salt Inducer 99.73% Yes
HY-19989A MK-571 sodium 99.24% Unkown
HY-P2974 Elastase, Porcine pancreas / Unkown
HY-100001 SKF-96365 hydrochloride 99.91% Unkown
HY-15754 CGP37157 Inhibitor 99.50% Unkown
HY-111925 BI-749327 Antagonist 99.50% Unkown
HY-B2060A Tiamulin fumarate Inhibitor ≥98.0% Unkown
HY-P1635 Pepsin / Unkown
HY-103447 Zearalenone Activator 98.50% Unkown
HY-106301 Devazepide Antagonist 99.58% Unkown
HY-B0519A Tylosin Inhibitor 99.81% Unkown
HY-101044 PPADS tetrasodium ≥95.0% Unkown
HY-121238 Hyocholic Acid 98.73% Unkown
HY-108511 PB28 dihydrochloride 99.97% Unkown
HY-106369 HMR 1556 Inhibitor 99.90% Unkown
HY-135976 P2X3 antagonist 34 Antagonist 99.71% Unkown
HY-13283 MF63 Inhibitor 99.55% Unkown
HY-106840 L-365260 Antagonist 99.93% Unkown
HY-P2831 Esterase, pig liver / Unkown
HY-103197 2-Methoxyidazoxan monohydrochloride Antagonist 99.20% Unkown
HY-15744 LY255283 Antagonist 98.52% Unkown
HY-101396 ICA-069673 Activator 99.65% Unkown
HY-B1340 Carbadox Inhibitor ≥98.0% Unkown
HY-15039 SSR240612 Antagonist 99.51% Unkown
HY-101408 Docosatrienoic Acid ≥99.0% Unkown
HY-101232 Tiotidine 99.28% Unkown
HY-16915 RPR-260243 Activator 99.37% Unkown
HY-12887 Piclamilast Inhibitor 99.63% Unkown
HY-128965 N-Glycolylneuraminic acid 99.90% Unkown
HY-14336A SB 271046 Hydrochloride Antagonist 99.93% Unkown
HY-17498S Atenolol-d7 Antagonist 96.67% Unkown
HY-50723 3-Methylxanthine 99.62% Unkown
HY-B1241 Dihydrostreptomycin sulfate Inhibitor ≥98.0% Unkown
HY-P1096 A71623 Agonist 99.90% Unkown
HY-B2060 Tiamulin 98.07% Unkown
HY-106961 ONO 1301 Agonist 99.06% Unkown
HY-108591 L-364,373 Activator 99.67% Unkown
HY-101222 SB-203186 hydrochloride 99.87% Unkown
HY-106840A L-365260 hemihydrate Antagonist 99.75% Unkown
HY-107384A Asimadoline hydrochloride Agonist 99.82% Unkown
HY-108594 PD-118057 Activator ≥99.0% Unkown
HY-P0263A Dermaseptin TFA Inhibitor 99.21% Unkown
HY-P1494 Substance P (1-9) 99.75% Unkown
HY-P2317 Cecropin P1, porcine Inhibitor 99.87% Unkown
HY-101341 RS 67333 hydrochloride Agonist 99.73% Unkown
HY-103447R Zearalenone (Standard) Activator 98.85% Unkown
HY-123801 MIDD0301 Modulator 98.14% Unkown
HY-N0757 8-​O-​Acetylharpagide Inhibitor 99.86% Unkown
HY-N10549 Gigantol 99.79% Unkown
HY-N8276 Ro 3-1314 Inhibitor ≥99.0% Unkown
HY-17597 Febantel Inhibitor 99.36% Unkown
HY-13402A Varespladib sodium Inhibitor ≥98.0% Yes
HY-100164 SDZ-MKS 492 Inhibitor 98.07% Unkown
HY-101343 RS 39604 Antagonist ≥98.0% Unkown
HY-103149 SB-216641A Antagonist ≥98.0% Unkown
HY-103158 BW B70C Inhibitor / Unkown
HY-107566 Conessine ≥98.0% Unkown
HY-107610 SR2640 hydrochloride Antagonist 99.60% Unkown
HY-107647A (R)-(+)-Dimethindene maleate Antagonist 99.94% Unkown
HY-121495 BKI-1369 Inhibitor 99.71% Unkown
HY-13213 AM211 Antagonist 98.11% Unkown
HY-134116 Isoflupredone acetate 98.55% Unkown
HY-148144A Clobutinol hydrochloride Inhibitor 99.22% Unkown
HY-150270A NP-1815-PX sodium Antagonist 99.62% Unkown
HY-50723S 3-Methylxanthine-13C4,15N3 / Unkown
HY-P1256C JMV 449 acetate Agonist 99.91% Unkown
HY-P2289A β-defesin 1 (pig) (TFA) Inhibitor 99.11% Unkown
HY-Y0032 Thiosemicarbazide Inhibitor ≥98.0% Unkown
HY-101676 RG-12525 98.31% Unkown
HY-19102 NSP-805 Inhibitor 99.28% Unkown
HY-B0519B Tylosin phosphate Inhibitor 98.08% Unkown
HY-N2106 Dehydroevodiamine 99.96% Unkown
HY-151198 CHF-6366 / Unkown
HY-19989 MK-571 / Unkown
HY-B0519AS Tylosin-d3 Inhibitor / Unkown
HY-100254 TAK-024 Inhibitor / Unkown
HY-103089 LY393558 Antagonist / Unkown
HY-103296 Bombinakinin M Agonist / Unkown
HY-103304 CGRP antagonist 4 / Unkown
HY-103447S (Rac)-Zearalenone-d6 / Unkown
HY-103447S1 Zearalenone-13C18 / Unkown
HY-105215 FK888 Antagonist / Unkown
HY-106150 Eniporide / Unkown
HY-106961A (Z)-ONO 1301 / Unkown
HY-107018 AR-A 2 Antagonist / Unkown
HY-107563 ROS 234 Antagonist / Unkown
HY-107563A ROS 234 dioxalate Antagonist / Unkown
HY-107611 Ro 24-5913 Antagonist / Unkown
HY-107644 AQ-RA 741 Antagonist / Unkown
HY-108511A PB28 / Unkown
HY-108561 L-670596 Antagonist / Unkown
HY-112739 SC-41930 Agonist / Unkown
HY-112742 CP-195543 Antagonist / Unkown
HY-113465A 11-trans Leukotriene E4 / Unkown
HY-113758 LY 163443 Antagonist / Unkown
HY-113829 Valnemulin Inhibitor / Unkown
HY-114538 Asobamast / Unkown
HY-114751 16,16-Dimethylprostaglandin E1 / Unkown
HY-114792 15-Methylprostaglandin E1 / Unkown
HY-114920 Piprofurol Inhibitor / Unkown
HY-116042 FSCPX Antagonist 99.72% Unkown
HY-116051 16,16-Dimethylprostaglandin F2α / Unkown
HY-116638 AHR-5333 Inhibitor / Unkown
HY-118463 Benzomalvin A / Unkown
HY-118546 JNJ-17156516 Antagonist / Unkown
HY-121520 Docosahexaenoyl glycine Activator / Unkown
HY-122331 Norbormide Inhibitor / Unkown
HY-123206 R-96544 free base Antagonist / Unkown
HY-126569 Efrotomycin Inhibitor / Unkown
HY-128043 11-Deoxy prostaglandin E1 / Unkown
HY-128965R N-Glycolylneuraminic acid (Standard) / Unkown
HY-129101 (-)-Eseroline fumarate Antagonist / Unkown
HY-130138B (5S,6R)-DiHETEs / Unkown
HY-131696 11-deoxy Prostaglandin F1α / Unkown
HY-135108 QWF Peptide Antagonist / Unkown
HY-13511AS Rupatadine-d4 fumarate / Unkown
HY-139112 Leukotriene B4 dimethyl amide / Unkown
HY-147014 Cyclic HPMPC Inhibitor / Unkown
HY-148038 5-HT3 antagonist 5 Antagonist 99.75% Unkown
HY-148144 Clobutinol Inhibitor / Unkown
HY-149942 PAP-IN-1 / Unkown
HY-150270 NP-1815-PX Antagonist / Unkown
HY-157796 β2AR agonist 4 Agonist / Unkown
HY-15791 FR173657 Antagonist / Unkown
HY-18600AS Azimilide-d8 dihydrochloride Inhibitor / Unkown
HY-19443 UCB-35440 / Unkown
HY-50723R 3-Methylxanthine (Standard) / Unkown
HY-A0168S Regadenoson-d3 Agonist / Unkown
HY-B1340S Carbadox-d3 Inhibitor / Unkown
HY-B2162C Chondroitin sulfate (from pig) 95.06% Unkown
HY-E70197 Calpain-1 (pig) / Unkown
HY-E70198 Pepsin (MS Grade) / Unkown
HY-E70231 Defibrase, deinagkistrodonacutus / Unkown
HY-N12520 Helveticoside / Unkown
HY-N3931 Gardneramine / Unkown
HY-N8671 Withanoside V / Unkown
HY-NP036 Pig Insulin-PE / Unkown
HY-P10006 Leumorphin, human Agonist / Unkown
HY-P1016 BQ-3020 Antagonist / Unkown
HY-P1016B BQ-3020 ammonium Agonist 99.18% Unkown
HY-P1112 Sarafotoxin S6a Agonist / Unkown
HY-P1112A Sarafotoxin S6a TFA Agonist / Unkown
HY-P1256 JMV 449 Agonist / Unkown
HY-P2289 β-defesin 1 (pig) Inhibitor / Unkown
HY-P2291 Beta-defensin 103 isoform X1, pig Inhibitor / Unkown
HY-P2291A Beta-defensin 103 isoform X1, pig TFA Inhibitor / Unkown
HY-P2317A Cecropin P1, porcine acetate Inhibitor / Unkown
HY-P2703 Peptide YY (pig) Activator / Unkown
HY-P3057 [D-Trp11]-Neurotensin Modulator / Unkown
HY-P3563 [Lys4] Sarafotoxin S6c Agonist / Unkown
HY-P4841 GLP-1 (7-36)-Lys(biotinyl) amide (human, bovine, guinea pig, mouse, rat) / Unkown
HY-RS10501 PIGS Human Pre-designed siRNA Set A / Unkown
HY-W127485 cis-9,10-Methyleneoctadecanoic Acid / Unkown
HY-101724 ReN-1869 hydrochloride Antagonist / Unkown
HY-101749 WAY127093B racemate Inhibitor / Unkown
HY-105872 Trifenagrel 99.35% Unkown
HY-106514 Prifelone Inhibitor / Unkown
HY-115381 Lipoxin A5 / Unkown
HY-116591 8-Iso-15-keto prostaglandin F2β / Unkown
HY-116606 LY108742 Antagonist / Unkown
HY-117557 LY306669 Antagonist / Unkown
HY-117706 LY 292728 Antagonist / Unkown
HY-120955 (+)-5-trans Cloprostenol / Unkown
HY-123596 LAS191859 Antagonist / Unkown
HY-130138A (5S,6R)-DiHETE / Unkown
HY-149589 11(Z),14(Z)-Eicosadienoic acid Inhibitor / Unkown
HY-156978 Ritolukast Antagonist / Unkown
HY-50723S1 3-Methylxanthine-d3 / Unkown
HY-D0808 Meldola blue / Unkown
HY-N10620 Melitidin / Unkown
HY-N3136 Onitin Antagonist / Unkown
HY-N3167 Nyasicoside / Unkown
HY-113442A 6-trans-Leukotriene B4 / Unkown
HY-101231 ICI-204448 98.68% Unkown
HY-101236 ICI 192605 / Unkown