1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Metabolic Enzyme/Protease
    Anti-infection
  2. Histamine Receptor
    Cytochrome P450
    Bacterial
  3. Ranitidine hydrochloride

Ranitidine hydrochloride 

Cat. No.: HY-B0281A Purity: ≥98.0%
Handling Instructions

Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9.

For research use only. We do not sell to patients.

Ranitidine hydrochloride Chemical Structure

Ranitidine hydrochloride Chemical Structure

CAS No. : 66357-59-3

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Other Forms of Ranitidine hydrochloride:

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Description

Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

Clinical Trial
Molecular Weight

350.86

Formula

C₁₃H₂₃ClN₄O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (142.51 mM)

DMSO : 50 mg/mL (142.51 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8501 mL 14.2507 mL 28.5014 mL
5 mM 0.5700 mL 2.8501 mL 5.7003 mL
10 mM 0.2850 mL 1.4251 mL 2.8501 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (313.52 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.93 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Ranitidine hydrochloride
Cat. No.:
HY-B0281A
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