2. Ranitidine bismuth citrate

Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC50 of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC90 value of 16 ng/L.

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Ranitidine bismuth citrate Chemical Structure

Ranitidine bismuth citrate Chemical Structure

CAS No. : 128345-62-0

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Ranitidine bismuth citrate Related Antibodies

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Description

Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC50 of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC90 value of 16 ng/L[1][2][3].

IC50 & Target

IC50: 3.3 μM[1]
In Vitro

Ranitidine bismuth citrate (0.1-1 μM, 5 min) is a potent irreversible inhibitor of both the ATPase (IC50=0.69 µM, Ki =0.97 µM ) and DNA-unwinding (IC50 =0.74 µM, Ki =0.39  µM) of the SARS-CoV-2 helicase[2].
Ranitidine bismuth citrate (24 hours) shows potent activity against SARS-CoV-2 with an EC50 value of 2.3 μM in Vero E6 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ranitidine bismuth citrate Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Monkey kidney Vero E6 cells, human colorectal Caco-2 cells
Concentration: 400-3,740 μM
Incubation Time: 48 hours
Result: Showed low cytotoxicity with the 50% cytotoxicity concentrations (CC50) ranging from 2.2 mM and 2.5 mM.
In Vivo

Ranitidine bismuth citrate (150 mg/kg; intranasally inoculation; once daily; 4 days) suppresses SARS-CoV-2 replication, and relieves virus-associated pneumonia in a golden Syrian hamster model[2].
Ranitidine bismuth citrate (48 mg/kg, i.p.) is effective in eradicating H. pylori and H. mustelae in female ferrests with MIC values of 8 ng/L and 1-2 ng/L, respectively[3].
Ranitidine bismuth citrate (0.1 mg/kg, 0.3 mg/kg; p.o.) is effective in inhibiting gastric acid secretion and (1.0 mM) inhibits human pepsin isoenzymes activity[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Syrian hamsters (6–10 weeks)[1]
Dosage: 150 mg/kg
Administration: Intranasally inoculation; intraperitoneally given; once daily; 4 days
Result: Suppressed SARS-CoV-2 replication, and relieved virus-associated pneumonia in a golden Syrian hamster model.
Animal Model: Female Beagle dogs (14-20 kg)[3]
Dosage: 0.1 mg/kg
Administration: Oral dosed every hour, for 5 hours
Result: Inhibited gastric acid secretion.
Animal Model: Female, random-bred hooded rats (weight range 90-120 g)[4]
Dosage: 0.5 mL/100 g
Administration: Pre-treated with indomethacin (5 mg/kg s.c.); oral gavage
Result: Inhibited gastric mucosal damage in the rat.
Molecular Weight

712.48

Formula

C19H27BiN4O10S
CAS No.
SMILES

O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-].O=C(CC(C([O-])=O)(O)CC([O-])=O)[O-].[Bi+3]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranitidine bismuth128345-62-0Inhibitorinhibitorinhibit

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