66357-59-3
Chemical Structure
Ranitidine hydrochloride
- CAS No.: 66357-59-3
- Formula:C13H23ClN4O3S
- Molecular Weight:350.86
IUPAC Name: (E)-N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride
InChIKey: GGWBHVILAJZWKJ-KJEVSKRMSA-N
SMILES: CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.Cl
Biological Activity: Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ranitidine hydrochloride | 99.86% | Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice. | ||||||||||||||||||||
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Ranitidine hydrochloride (Standard) | ≥98% | Ranitidine hydrochloride (Standard) is the analytical standard of Ranitidine hydrochloride (HY-B0281A). This product is intended for research and analytical applications. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice. | ||||||||||||||||||||
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Ranitidine-d6 hydrochloride | 97.00% | Ranitidine-d6 hydrochloride is the deuterium labeled Ranitidine hydrochloride (HY-B0281A). Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice. | ||||||||||||||||||||
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Similarity Score 0.98
HY-B0693Ranitidine -
Similarity Score 0.86
HY-126875Ranitidine impurity 12 -
Similarity Score 0.84
HY-W011245RRanitidine S-oxide (Standard) -
Similarity Score 0.81
HY-B0693SRanitidine-d6 -
Similarity Score 0.78
HY-Z2517Ranitidine impurity 8 -
Similarity Score 0.73
HY-B0693ARanitidine bismuth citrate -
Similarity Score 0.71
HY-B0310Nizatidine -
Similarity Score 0.70
HY-W013109Ranitidine impurity 15 -
Similarity Score 0.68
HY-182427ORF 17583 -
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References
- [1]. Daly MJ, et al. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981 Jan;72(1):49-54. [Content Brief]
- [2]. Vila-Leahey A, et al. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016 Mar 10;5(7):e1151591. [Content Brief]
