Ranitidine-d6 hydrochloride
Based on 1 Customer Validation
Ranitidine-d6 hydrochloride is the deuterium labeled Ranitidine hydrochloride (HY-B0281A). Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice.
For research use only. We do not sell to patients.
- Purity: 97.00%
- CAS No.: 1185238-09-8
- Formula: C13H17D6ClN4O3S
- Molecular Weight:356.90
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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H2 Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185238-09-8
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Unlabeled Cas 66357-59-3
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Appearance Solid
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Molecular Weight 356.90
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Formula C13H17D6ClN4O3S
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Color Yellow to brown
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SMILES
[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC1=CC=C(CSCCN/C(NC)=C/[N+]([O-])=O)O1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (140.10 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Daly MJ, et al. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981 Jan;72(1):49-54. [Content Brief]
[3]. Vila-Leahey A, et al. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016 Mar 10;5(7):e1151591. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.8019 mL | 14.0095 mL | 28.0191 mL | 70.0476 mL |
| 5 mM | 0.5604 mL | 2.8019 mL | 5.6038 mL | 14.0095 mL | |
| 10 mM | 0.2802 mL | 1.4010 mL | 2.8019 mL | 7.0048 mL | |
| 15 mM | 0.1868 mL | 0.9340 mL | 1.8679 mL | 4.6698 mL | |
| 20 mM | 0.1401 mL | 0.7005 mL | 1.4010 mL | 3.5024 mL | |
| 25 mM | 0.1121 mL | 0.5604 mL | 1.1208 mL | 2.8019 mL | |
| 30 mM | 0.0934 mL | 0.4670 mL | 0.9340 mL | 2.3349 mL | |
| 40 mM | 0.0700 mL | 0.3502 mL | 0.7005 mL | 1.7512 mL | |
| 50 mM | 0.0560 mL | 0.2802 mL | 0.5604 mL | 1.4010 mL | |
| 60 mM | 0.0467 mL | 0.2335 mL | 0.4670 mL | 1.1675 mL | |
| 80 mM | 0.0350 mL | 0.1751 mL | 0.3502 mL | 0.8756 mL | |
| 100 mM | 0.0280 mL | 0.1401 mL | 0.2802 mL | 0.7005 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ranitidine-d6 hydrochloride Related Classifications
HY-B0281AS Related Classifications
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