NSP-805

Cat. No.: HY-19102 Purity: 99.28%: FAQs
Data Sheet SDS COA Handling Instructions

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NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.

For research use only. We do not sell to patients.

NSP-805 Chemical Structure

CAS No. : 125068-54-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 264	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 264	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 408	In-stock	Estimated Time of Arrival: December 31
20 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties.

In Vitro

In isolated guinea pig left atria, NSP-805 shows positive inotropic EC₅₀ value in order of potency of 0.18 μM. The in vitro positive inotropic effects of NSP-805 is accompanied by increases in tissue cyclic AMP and abolished by carbachol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In anesthetized dogs, intravenous (i.v.) injection of NSP-805 produces dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR). The ED₅₀ value for LVdP/dtmax of NSP-805 is 12 μg/kg. When the drugs is administered intraduodenally to anesthetized dogs, the ED₅₀ value for LVdP/dtmax of NSP-805, is approximately 10 μg/kg. In the propranolol-induced heart failure model, NSP-805 completely improves the hemodynamic state of heart failure to normal levels^[1]. NSP-805(100 μg/kg) reduces systemic blood pressure significantly, but the increase of chorio-retinal blood flow is less than that at the low dose of NSP-805 (40 μg/kg) in rabbit eyes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.35

Formula

C₁₇H₁₉N₃O₂

CAS No.

125068-54-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1CC(C)C(C2=CC=C(NC3=C(C)C(CC3)=O)C=C2)=NN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL (140.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3630 mL	16.8152 mL	33.6304 mL
5 mM	0.6726 mL	3.3630 mL	6.7261 mL
10 mM	0.3363 mL	1.6815 mL	3.3630 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) HNMR (267 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95. [Content Brief]

[2]. Uchida H, et al. [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai Zasshi. 2002 Oct;106(10):615-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3630 mL	16.8152 mL	33.6304 mL	84.0760 mL
	5 mM	0.6726 mL	3.3630 mL	6.7261 mL	16.8152 mL
	10 mM	0.3363 mL	1.6815 mL	3.3630 mL	8.4076 mL
	15 mM	0.2242 mL	1.1210 mL	2.2420 mL	5.6051 mL
	20 mM	0.1682 mL	0.8408 mL	1.6815 mL	4.2038 mL
	25 mM	0.1345 mL	0.6726 mL	1.3452 mL	3.3630 mL
	30 mM	0.1121 mL	0.5605 mL	1.1210 mL	2.8025 mL
	40 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1019 mL
	50 mM	0.0673 mL	0.3363 mL	0.6726 mL	1.6815 mL
	60 mM	0.0561 mL	0.2803 mL	0.5605 mL	1.4013 mL
	80 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0510 mL
	100 mM	0.0336 mL	0.1682 mL	0.3363 mL	0.8408 mL

NSP-805 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSP-805125068-54-4NSP805NSP 805Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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