2. GPCR/G Protein
  3. Leukotriene Receptor
  4. SM-15178

SM-15178 is a potent, orally active and selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM. SM-15178 attenuates LTB4 (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma.

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SM-15178

SM-15178 Chemical Structure

CAS No. : 146461-98-5

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SM-15178 Related Antibodies

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Description

SM-15178 is a potent, orally active and selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM. SM-15178 attenuates LTB4 (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma[1][2][3].

IC50 & Target

LTB4

0.30 μM (IC50)

In Vitro

SM-15178 (30 min) inhibits LTB4 binding to human neutrophils in a dose-dependent manner (IC50 = 0.30 μM)[3].
SM-15178 (up to 30 μM; 15-90 min) inhibits LTB4-induced chemotaxis of mouse and rat neutrophils and guinea pig eosinophils (IC50 = 0.52-0.72 μM)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SM-15178 Related Antibodies
In Vivo

SM-15178 (5 mg/kg; i.v.; single dose) reduces LTB4-induced cutaneous neutrophil accumulation in mice[1].
SM-15178 (5 mg/kg; i.v.; 2-30 min pre-LTB4, or 40 mg/kg; p.o.; 60 min pre-LTB4) potently inhibits LTB4-induced bronchoconstriction in guinea pigs[2].
SM-15178 (20-40 mg/kg; p.o.; single dose) suppresses LTB4-induced transient leukopenia in guinea pigs[3].
SM-15178 (5-100 mg/kg; p.o.; single dose) suppresses Arachidonic Acid-induced neutrophil infiltration in mice[3].
SM-15178 (10-100 mg/kg; p.o.; one day or 1 h before SRBC challenge) inhibits sheep red blood cells (SRBC)-induced paw edema in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6N mice induced by LTB4[1]
Dosage: 5 mg/kg
Administration: i.v.; single dose
Result: Significantly reduced LTB4-induced neutrophil accumulation by 70.3%.
Animal Model: Guinea pigs challenged with LTB₄[2]
Dosage: 5 mg/kg (i.v.); 40 mg/kg (p.o.)
Administration: i.v.; 2, 10, or 30 min pre-LTB₄; p.o.; 60 min pre-LTB₄
Result: Showed potent inhibitory activity against LTB₄-induced bronchoconstriction at all dosages.
Animal Model: Male Hartley Guinea pigs (400-450 g) intravenously injected with LTB₄[3]
Dosage: 20, 40 mg/kg
Administration: p.o.; single dose; 1 h pre-LTB4
Result: Significantly suppressed LTB₄-induced transient leukopenia and LTB₄-induced bronchoconstriction.
Animal Model: Male BALB/c (20-30 g) topically applied with Arachidonic Acid[3]
Dosage: 5, 25, 50, 100 mg/kg
Administration: p.o.; single dose
Result: Suppressed arachidonic acid-induced increases in myeloperoxidase (MPO) levels in a dose-dependent manner.
Animal Model: Male BALB/c (25-30 g) injected with SRBC[3]
Dosage: 10, 25, 50, 100 mg/kg
Administration: p.o.; one day or 1 hour before SRBC
Result: Inhibited Arthus reaction-induced paw edema in a dose-dependent manner with a minimum effective dose of 25 mg/kg.
Molecular Weight

414.46

Formula

C22H26N2O6
CAS No.
SMILES

O=C(O)CCN(C(=O)C=1N=C(C=CC1)COC2=CC(O)=C(C=C2CC)C(=O)C)CC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SM-15178 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM-15178146461-98-5SM15178SM 15178Leukotriene ReceptorLTB4 receptorFMLPguinea pigsmale Hartley guinea pigsC5aneutrophilmouse skinLTB4leukotriene B4male C57BL/6N miceInhibitorinhibitorinhibit

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