146461-98-5
Chemical Structure
SM-15178
- CAS No.: 146461-98-5
- Formula:C22H26N2O6
- Molecular Weight:414.46
IUPAC Name: 3-(6-((4-acetyl-2-ethyl-5-hydroxyphenoxy)methyl)-N-ethylpicolinamido)propanoic acid
InChIKey: AQFYLVCUNGCYNH-UHFFFAOYSA-N
SMILES: O=C(O)CCN(C(=O)C=1N=C(C=CC1)COC2=CC(O)=C(C=C2CC)C(=O)C)CC
Biological Activity: SM-15178 is a potent, orally active and selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM. SM-15178 attenuates LTB4 (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma[1][2][3].
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SM-15178 | SM-15178 is a potent, orally active and selective leukotriene B4 (LTB4) receptor antagonist with an IC50 of 0.30 μM. SM-15178 attenuates LTB4 (HY-107608)-induced neutrophil accumulation in mouse skin and bronchoconstriction in guinea pigs. SM-15178 emonstrates significant anti-inflammatory efficacy across multiple animal models of inflammation. SM-15178 can be used for the research of chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, and asthma. | |||||||||||||||||||||
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References
- [1]. Ohnishi M, et al. Role of P-selectin in the migration of neutrophils to chemoattractant-induced cutaneous inflammation in mice. Inflammation. 2000;24(6):583-593. [Content Brief]
- [2]. Hajime KawakamiSynthesis of new potent leukotriene B4 antagonists and their biological properties. 2. Bioorganic & Medicinal Chemistry Letters. Volume 4, Issue 12, 23 June 1994, Pages 1461-1466.
- [3]. Ohmi N, et al. Pharmacological profile of a novel, orally active leukotriene B4 antagonist, SM-15178. Inflammation. 1994;18(2):129-140. [Content Brief]
