Leukotriene B4
Based on 9 publication(s) in Google Scholar
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 71160-24-2
- Formula: C20H32O4
- Molecular Weight:336.47
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Leukotriene B4
More- Cell Metab. 2026 Jan 9:S1550-4131(25)00546-7. [Abstract]
- Cell Stem Cell. 2026 Aug 6;33(8):1363-1378.e9.
- Cell Rep. 2026 Apr 7;45(4):117220. [Abstract]
- J Med Chem. 2025 Oct 15. [Abstract]
- J Med Chem. 2025 Jun 12;68(11):11127-11148. [Abstract]
- ACS Pharmacol Transl Sci. 2025 Oct 4;8(11):4095-4106. [Abstract]
- Biochem Biophys Res Commun. 2026 Sep 17:831:154324.
- Head Neck. 2025 Feb;47(2):504-516. [Abstract]
- Northwestern University. 2026.
All Endogenous Metabolite Isoforms
MoreAll PROTAC Linkers Isoforms
MoreAll Leukotriene Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
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Alkyl-Chain |
Human Endogenous Metabolite |
In Vitro
Leukotriene B4 induces recruitment and activation of neutrophils, monocytes and eosinophils. It also stimulates the production of a number of proinflammatory cytokines and mediators indicating an ability to augment and prolong tissue inflammation[2].
Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 71160-24-2
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Appearance Liquid
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Molecular Weight 336.47
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Formula C20H32O4
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
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Synonyms
LTB4; 5(S),12(R)-DiHETE
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (9)
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Journal Impact Factor
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Most Recent
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Cell Metab
2026 Jan 9:S1550-4131(25)00546-7. PMID: 41519131 -
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Cell Rep
Bach2 antagonizes leukotriene B4-Ltb4r1-JunB signaling to constrain Tfh13 cell differentiation. [Abstract]2026 Apr 7;45(4):117220. PMID: 41950005 -
J Med Chem
Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis. [Abstract]2025 Oct 15. PMID: 41088966 -
J Med Chem
Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity. [Abstract]2025 Jun 12;68(11):11127-11148. PMID: 40387207 -
ACS Pharmacol Transl Sci
Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. [Abstract]2025 Oct 4;8(11):4095-4106. PMID: 41262585 -
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Head Neck
2025 Feb;47(2):504-516. PMID: 39290130 -
Purity & Documentation
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Data Sheet (266 KB)
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SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leukotriene B4 Related Classifications
HY-107608 Related Classifications
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