1. Metabolic Enzyme/Protease PROTAC GPCR/G Protein
  2. PROTAC Linkers Endogenous Metabolite Leukotriene Receptor
  3. Leukotriene B4

Leukotriene B4  (Synonyms: LTB4; 5(S),12(R)-DiHETE)

Cat. No.: HY-107608 Purity: ≥98.0%
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Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Leukotriene B4 Chemical Structure

Leukotriene B4 Chemical Structure

CAS No. : 71160-24-2

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25 μg (297.2 µM * 250 μL in Ethanol) USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].

IC50 & Target

Alkyl-Chain

 

Human Endogenous Metabolite

 

In Vitro

Leukotriene B4 induces recruitment and activation of neutrophils, monocytes and eosinophils. It also stimulates the production of a number of proinflammatory cytokines and mediators indicating an ability to augment and prolong tissue inflammation[2].
Leukotriene B4 is a pro-inflammatory mediator synthesised in myeloid cells from arachidonic acid[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

336.47

Formula

C20H32O4

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Leukotriene B4
Cat. No.:
HY-107608
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