2. Others Neuronal Signaling GPCR/G Protein
  3. Drug Isomer Adrenergic Receptor
  4. (S,S)-BRL-37344

(S,S)-BRL-37344 is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes.

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(S,S)-BRL-37344

(S,S)-BRL-37344 Chemical Structure

CAS No. : 90730-96-4

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Based on 1 publication(s) in Google Scholar

Other Forms of (S,S)-BRL-37344:

(S,S)-BRL-37344 Related Antibodies

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Description

(S,S)-BRL-37344 is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes[1].

In Vitro

(S,S)-BRL-37344 shows EC50 >1000 nM forβ3, β2 and β1[1].
(S,S)-BRL-37344 does not induce concentration-dependent increases in atria1 rate and weakly induces relaxation of guinea pig trachea[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,S)-BRL-37344 Related Antibodies
Molecular Weight

363.84

Formula

C19H22ClNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(C[C@@H](NC[C@H](C2=CC=CC(Cl)=C2)O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.5 M NaOH : ≥ 100 mg/mL (274.85 mM)

DMSO : 20 mg/mL (54.97 mM; ultrasonic and adjust pH to 3 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7485 mL 13.7423 mL 27.4846 mL
5 mM 0.5497 mL 2.7485 mL 5.4969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.5 M NaOH 1 mM 2.7485 mL 13.7423 mL 27.4846 mL 68.7115 mL
5 mM 0.5497 mL 2.7485 mL 5.4969 mL 13.7423 mL
10 mM 0.2748 mL 1.3742 mL 2.7485 mL 6.8712 mL
15 mM 0.1832 mL 0.9162 mL 1.8323 mL 4.5808 mL
20 mM 0.1374 mL 0.6871 mL 1.3742 mL 3.4356 mL
25 mM 0.1099 mL 0.5497 mL 1.0994 mL 2.7485 mL
30 mM 0.0916 mL 0.4581 mL 0.9162 mL 2.2904 mL
40 mM 0.0687 mL 0.3436 mL 0.6871 mL 1.7178 mL
50 mM 0.0550 mL 0.2748 mL 0.5497 mL 1.3742 mL
0.5 M NaOH 60 mM 0.0458 mL 0.2290 mL 0.4581 mL 1.1452 mL
80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8589 mL
100 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6871 mL
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(S,S)-BRL-37344 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,S)-BRL-3734490730-96-4Drug IsomerAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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