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Cat. No.: HY-101325B

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BRL-37344

BRL-37344 is a β-adrenoceptor agonist with EC₅₀ values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes.

For research use only. We do not sell to patients.

CAS No.: 114333-71-0
Formula: C₁₉H₂₂ClNO₄
Molecular Weight:363.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BRL-37344 Chemical Structure

CAS No.: 114333-71-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

β3 adrenoceptor

5.3 nM (EC₅₀)

β2 adrenoceptor

18 nM (EC₅₀)

β1 adrenoceptor

570 nM (EC₅₀)

All Adrenergic Receptor Isoforms :

In Vitro

BRL-37344 (0.1 nM-10 μM) induces concentration-dependent increases in atria1 rate with an EC₅₀ value of 0.57 μM and induces relaxation of guinea pig trachea with an EC₅₀ value of 18 nM^[1].
BRL-37344 (0.1 nM-1 μM) induces concentration-dependent lipolysis of brown adipocytes with an EC₅₀ value of 5.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 114333-71-0
Molecular Weight 363.84
Formula C₁₉H₂₂ClNO₄
SMILES

O=C(COC1=CC=C(CC(C)NCC(C2=CC(Cl)=CC=C2)O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ida K, et al. Stereoselective action of (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl)ethylamino] propyl]-phenoxyacetic acid (BRL37344) on beta-adrenoceptors and metabolic chiral inversion. Biochem Pharmacol. 1996;52(10):1521-1527. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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