(S,S)-BRL-37344 sodium
Based on 1 Customer Validation
(S,S)-BRL-37344 sodium is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 127299-93-8
- Formula: C19H21ClNNaO4
- Molecular Weight:385.82
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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All Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
(S,S)-BRL-37344 sodium shows EC50 >1000 nM forβ3, β2 and β1[1].
(S,S)-BRL-37344 sodium does not induce concentration-dependent increases in atria1 rate and weakly induces relaxation of guinea pig trachea[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old male Imprinting Control Region (ICR) mice[1]
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Dosage:2.5 mg/kg
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Administration:Intraperitoneal injection; three times per week for two weeks
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Result:Lowered the body weight of obese mice.
Chemical Information
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CAS No. 127299-93-8
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Appearance Solid
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Molecular Weight 385.82
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Formula C19H21ClNNaO4
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Color White to off-white
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SMILES
O=C(O[Na])COC1=CC=C(C[C@@H](NC[C@H](C2=CC=CC(Cl)=C2)O)C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 5 mg/mL (12.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (25.92 mM); Clear solution; Need ultrasonic and warming
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5919 mL | 12.9594 mL | 25.9188 mL | 64.7971 mL |
| 5 mM | 0.5184 mL | 2.5919 mL | 5.1838 mL | 12.9594 mL | |
| 10 mM | 0.2592 mL | 1.2959 mL | 2.5919 mL | 6.4797 mL |
(S,S)-BRL-37344 sodium Related Classifications
HY-101325 Related Classifications
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