2. Others Neuronal Signaling GPCR/G Protein
  3. Drug Isomer Adrenergic Receptor
  4. (S,S)-BRL-37344 sodium

(S,S)-BRL-37344 sodium is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes.

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(S,S)-BRL-37344 sodium

(S,S)-BRL-37344 sodium Chemical Structure

CAS No. : 127299-93-8

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Based on 1 publication(s) in Google Scholar

Other Forms of (S,S)-BRL-37344 sodium:

(S,S)-BRL-37344 sodium Related Antibodies

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Description

(S,S)-BRL-37344 sodium is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC50 values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes[1].

IC50 & Target

β adrenergic receptor

 

In Vitro

(S,S)-BRL-37344 sodium shows EC50 >1000 nM forβ3, β2 and β1[1].
(S,S)-BRL-37344 sodium does not induce concentration-dependent increases in atria1 rate and weakly induces relaxation of guinea pig trachea[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,S)-BRL-37344 sodium Related Antibodies
In Vivo
Animal Model: Five-week-old male Imprinting Control Region (ICR) mice[1]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection; three times per week for two weeks
Result: Lowered the body weight of obese mice.
Molecular Weight

385.82

Formula

C19H21ClNNaO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])COC1=CC=C(C[C@@H](NC[C@H](C2=CC=CC(Cl)=C2)O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5919 mL 12.9594 mL 25.9188 mL
5 mM 0.5184 mL 2.5919 mL 5.1838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (25.92 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

SDS (252 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5919 mL 12.9594 mL 25.9188 mL 64.7971 mL
5 mM 0.5184 mL 2.5919 mL 5.1838 mL 12.9594 mL
10 mM 0.2592 mL 1.2959 mL 2.5919 mL 6.4797 mL
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(S,S)-BRL-37344 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,S)-BRL-37344127299-93-8Drug IsomerAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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