5-LOX-IN-9
Based on 1 Customer Validation
5-LOX-IN-9 is a 5-lipoxygenase and cyclooxygenase inhibitor, with an IC50 of 0.2 pM against guinea pig 5-LOX and an IC50 of 0.7 pM against bovine COX. 5-LOX-IN-9 inhibits 5-lipoxygenase via a redox-mediated mechanism. 5-LOX-IN-9 inhibits cyclooxygenase through hydrogen donor action and hydrophobicity-dependent activity.
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- CAS. Nr.: 2668-47-5
- Formel: C20H26O
- Molecular Weight:282.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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5-LOX 0.2 pM (IC50, guinea pig) |
5-LOX 0.7 pM (IC50, bovine) |
5-LOX-IN-9 (Compound 3) acts as a dual inhibitor, potently inhibiting bovine seminal vesicle COX with an IC50 of 7 × 10-7 μM and guinea pig lung 5-LOX with an IC50 of 2 × 10-7 μM[1].
5-LOX-IN-9 in its cis-b conformation exhibits an MEP map with an extended negative region around its R3 aromatic ring, a feature associated with dual COX/5-LOX inhibitory activity[1].
5-LOX-IN-9 in its cis-b conformation has dual hydrophobic interaction areas (consistent with dual COX/5-LOX inhibition) and a strong ferric iron cation interaction, which correlates with its potent 5-LOX inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2668-47-5
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Molecular Weight 282.43
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Formel C20H26O
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SMILES
OC=1C(=CC(=CC1C(C)(C)C)C=2C=CC=CC2)C(C)(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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