JMV 449 acetate
Based on 1 Customer Validation
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.
For research use only. We do not sell to patients.
- Purity: 99.69%
- Formula: C40H70N8O9
- Molecular Weight:807.03
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss albino mice[1]
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Dosage:120 pmol/mouse
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Administration:I.c.v.
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Result:Showed dose-response relation-ships for the analgesic effect.
Chemical Information
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Appearance Solid
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Molecular Weight 807.03
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Formula C40H70N8O9
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (123.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198. [Content Brief]
[2]. Dubuc I, et al. JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2391 mL | 6.1956 mL | 12.3911 mL | 30.9778 mL |
| 5 mM | 0.2478 mL | 1.2391 mL | 2.4782 mL | 6.1956 mL | |
| 10 mM | 0.1239 mL | 0.6196 mL | 1.2391 mL | 3.0978 mL | |
| 15 mM | 0.0826 mL | 0.4130 mL | 0.8261 mL | 2.0652 mL | |
| 20 mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.5489 mL | |
| 25 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2391 mL | |
| 30 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL | |
| 40 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7744 mL | |
| 50 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6196 mL | |
| 60 mM | 0.0207 mL | 0.1033 mL | 0.2065 mL | 0.5163 mL | |
| 80 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL | |
| 100 mM | 0.0124 mL | 0.0620 mL | 0.1239 mL | 0.3098 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
JMV 449 acetate Related Classifications
HY-P1256C Related Classifications
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