1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. JMV 449 acetate

JMV 449 acetate 

Cat. No.: HY-P1256C Purity: 99.84%
Handling Instructions

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

JMV 449 acetate Chemical Structure

JMV 449 acetate Chemical Structure

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5 mg USD 800 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

In Vivo

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice[1]
Dosage: 120 pmol/mouse
Administration: I.c.v.
Result: Showed dose-response relation-ships for the analgesic effect.
Molecular Weight

807.03

Formula

C₄₀H₇₀N₈O₉

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

JMV 449JMV449JMV-449Neurotensin Receptorpseudopeptideanalogueneurotensin8-13hypothermicneuroprotectiveInhibitorinhibitorinhibit

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Product Name:
JMV 449 acetate
Cat. No.:
HY-P1256C
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