1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Neurotensin Receptor
  4. NTR1 Isoform


NTR1 (neurotensin receptor 1) belongs to the large superfamily of G-protein coupled receptors and is considered a class-A GPCR. NTSR1 mediates multiple biological processes through modulation by neurotensin, such as low blood pressure, high blood sugar, low body temperature, antinociception, anti-neuronal damage and regulation of intestinal motility and secretion.

NTR1 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-125880
    Modulator 99.86%
    SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM.
  • HY-16639
    Agonist 99.82%
    ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization.