Fmoc-DL-Leu-OH 

Fmoc-DL-Leu-OH acts as a partial agonist of the neurotensin NTS1 receptor (NTS1R) with an EC₅₀ of 215.50 μM. Fmoc-DL-Leu-OH triggers intracellular calcium mobilization, and its activity is blocked by selective NTS1R antagonists. Fmoc-DL-Leu-OH can be used in the research of schizophrenia^[1].

Fmoc-DL-Leu-OH (Compound 1) acts as a partial agonist of human NTS1R expressed in CHOK1 cells, with an EC₅₀ of 215.50 μM and a potency reaching 60% of the maximum potency of NT^[1].
Fmoc-DL-Leu-OH (50 μM) exhibited agonist activity at human NTS1R expressed in CHOK1 cells, which was blocked by the selective NTS1R antagonist SR-48692 with an IC₅₀ of 3.79 nM^[1].
Fmoc-DL-Leu-OH (60 min) shows no detectable binding to human NTS1R in a [³H]neurotensin competitive binding assay performed using stably transfected CHOK1 cell membranes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

353.42

C₂₁H₂₃NO₄

126727-03-5

O=C(OCC1C=2C=CC=CC2C=3C=CC=CC31)NC(C(=O)O)CC(C)C

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• [1]. Fan Y, et al. The identification of neurotensin NTS1 receptor partial agonists through a ligand-based virtual screening approach. Bioorg Med Chem Lett. 2008;18(21):5789-5791.  [Content Brief]